Publications
2021
Marshall, N., M. Baxi, C. MacDonald, C. Sikora, and G.J. Tyrrell. 2021. Ten years of diphtheria toxin testing and toxigenic cutaneous diphtheria investigations in Alberta, Canada: a highly vaccinated population. Open Forum Infectious Diseases (OFID). August 2021. doi.org/10.1093/ofid/ofab414.
DebRoy, S., M. Sanson, B. Shah, S. Regmi, L.A. Vega, C. Odo, P. Sahasrabhojane, A. McGeer, G.J. Tyrrell, N. Fittipaldi, A.A. Shelburne and A.R. Flores. 2021. Population genomics of emm4 group A Streptococcus in North America reveals clonal replacement with a hypervirulent clone in North America. mSystems. 2021 Aug 10:e0049521. doi: 10.1128/mSystems.00495-21. PMID: 34374563.
Tyrrell, G.J., C. Lee, and D. Eurich. 2021. Is there a need for pneumococcal vaccination programs for the homeless to prevent invasive pneumococcal disease? Invited by Editor. Expert Review of Vaccines. 2021 Aug. DOI: 10.1080/14760584.2021.1966301. PMID: 34365882.
Kellner, J., L. Ricketson, O. Vanderkooi, G.J. Tyrrell, W. Demczuk, I. Martin and M. Mulvey. 2021. Whole genome phylogenetic analysis and clinical features of Streptococcus pneumoniae serotype 4 causing invasive pneumococcal disease in Alberta. Emerging Infectious Diseases. 2021 July, 27(7):1876-1875. PMID: 34152965.
Hulbah, M., M. Croxen and G.J. Tyrrell. 2021. Phenotypic changes in Group B streptococci grown in the presence of the polyols, erythritol, sorbitol and mannitol. BMC Microbiology. 2021 May 13;21(1):145. doi: 10.1186/s12866-021-02208-z. PMID: 33905431.
Tyrrell, G.J. 2021. Does group A strep have any skin in the ARF game? The Lancet Regional Health: Western Pacific. Commentary-Invited by Editor. 2021 March. doi.org/10.1016/j.lanwpc.2021.100114. PMID: 34327432.
Tyrrell, G.J., C. Bell, L. Bill and S. Fathima. 2021. Increasing incidence rates of invasive group A streptococcal disease in the First Nations population in Alberta, Canada, 2003-2017. Emerging Infectious Diseases. 2021 January, 27(2):443-451. PMID: 33496247.
2020
Kleinman, D., J. Lam, J. Bacani, G.J. Tyrrell and S.L. Turvey. 2020. Bartonella quintana infective endocarditis in northern Alberta: a case report. Journal of Association of Medical Microbiology and Infectious Diseases (JAMMI). December 2020: https://doi.org/10.3138/jammi-2020-0013.
Friedman, D., C. Cervera, K. Halloran, G.J. Tyrrell and K. Doucette. 2020. Nontuberculous mycobacteria in lung transplant recipients: Prevalence, risk factors and impact on survival and chronic lung allograft dysfunction. Transplant Infectious Diseases. 2020 Apr;22(2):e13229. doi: 10.1111/tid.13229. PMID: 31794120.
Tsang, R., M. Shuel, T. Ahmad, K. Hayden, N. Knox, G. Van Domselaar, L. Hoang, G. J. Tyrrell, J. Minion, P. Van Caeseele, J. V Kus, M. Ulanova, B. Lefebvre, D. Haldane, R. Garceau, G. German, G. Zahariadis, Brenden Hanley, K. Kondola, M. Patterson. 2020. Whole Genome Sequencing to study the phylogenetic structure of serotype a Haemophilus influenzae recovered from patients in Canada. Canadian Journal of Microbiology. 2020 Feb;66(2):99-110. doi: 10.1139/cjm-2019-0406. PMID: 31661630
2019
Dey, R., H. Mount, A.W. Ensminger, G.J. Tyrrell, L.P Ward, and N.J. Ashbolt. 2019. Isolation of Legionella pneumophila by coculture with local ameba, Canada. Emerging Infectious Diseases. 25(11): 2104-2107. PMID: 31625866.
Pandey, M., A. Calcutt, V. Ozberk, M. Croxen, J. Powell, E. Langshaw, J. Mills, F. Jen, M. Jennings, J. Robson, G.J. Tyrrell and M. Good. 2019. Antibodies to the conserved region of the M protein and a streptococcal super antigen cooperatively resolve toxic shock-like syndrome in HLA humanized mice. Science Advances. http://advances.sciencemag.org/content/5/9/eaax3013. PMID: 31517054.
Tsang, R.S.W., L. Hoang, G.J. Tyrrell, J. Minion, P. Van Caeseele, J. Kus, B. Lefebvre, D. Haldane, R. Garceau, G. German, G. Zahariadis and B. Hanley. 2019. Continued increase in invasive meningococcal disease due to the ST-11 serogroup W Neisseria meningitidis in Canada, 2016-2018. Canada Communicable Disease Reports. 45(6):164-169. PMID: 31285709.
Lau, D., R. Cooper, J. Chen, V. Sim, J. McCombe, G.J. Tyrrell, R. Bhargava, B. Adam, E. Chapman, M. Croxen, C. Garady, K. Antonation, F. Landeghem, S. Ip, L. Saxinger. 2019. Mycobacterium chimaera encephalitis post-cardiac surgery: a new syndrome. Clinical Infectious Disease. 70(4): 692-695. PMID: 31247065.
Tsang, R.S.W., T. Ahmad, F. Jamieson and G.J. Tyrrell. 2019. WGS analysis of a penicillin-resistant Neisseria meningitidis strain containing a chromosomal ROB-1 β-lactamase gene. Journal of Antimicrobial Chemotherapy. 74(1): 22-28. PMID: 30295754.
2018
Tyrrell, G.J., S. Fathima, J. Kakulphimp and C. Bell. 2018. Increasing rates of Invasive Group A streptococcal disease in Alberta, Canada; 2003-2017. Open Forum Infectious Diseases. Jul 20; 5(8):ofy177. doi: 10.1093/ofid/ofy177. eCollection 2018 Aug. PMID: 30109241.
Alhhazmi, A, and G.J. Tyrrell. 2018. Phenotypic and molecular analysis of nontypeable Group B streptococci: identification of cps2a and hybrid cps2a/cps5 Group B streptococcal capsule gene clusters. Emerging Microbes and Infection. 2018 Aug 8; 7(1):137. doi: 10.1038/s41426-018-0138-6. PMID: 30087323.
Doroshenko, A., C. Pepperell, C. Heffernan, M.L Egedahl, T. Mortimer, T. Smith, T. Mortimer, H.E. Bussan, G.J. Tyrrell, R. Long. 2018. Epidemiological and genomic determinates of tuberculosis outbreaks in First Nations communities in Alberta, Canada. BMC Medicine. 16(1): 128 doi: 10.1186/s12916-018-1112-9. PMID: 30086755.
Demczuk, W., I. Martin, S. Desai, A. Griffith, B. Lefebvre, A. McGeer, G.J. Tyrrell, G. Zhanel, J. Gubbay, L. Hoang, P. Levett, P. van Caeseele, R. Raafat Gad, D. Haldane, G. Zahariadis, G. German, J. Daley Bernier, L. Strudwick and M.R. Mulvey. 2018. Serotype distribution of invasive Streptococcus pneumoniae in adults 65 years of age and over after the introduction of childhood 13-valent pneumococcal conjugate vaccination programs in Canada, 2010-2016. Vaccine. 36(3): 4701-4707. PMID: 29937245.
Sander, M.A., J.L. Isaac-Renton, G.J. Tyrrell. 2018. Cutaneous nontuberculous mycobacterial infections in Alberta, Canada: An epidemiologic study, and review. Journal of Cutaneous Medicine and Surgery. 22(5): 479-483. PMID: 29772918.
Marrie, T.J., G.J. Tyrrell, S.R. Majumdar and D.T. Eurich. 2018. Invasive Pneumococcal Disease in Northern Alberta, not a Red Queen but a Dark Horse. Vaccine. 2018 36(21): 2985-2990. PMID: 29615595.
Teatero, S., A. McGeer, G.J. Tyrrell, L. Hoang, H. Smadi, M. Domingo, P. Levett, M. Finkelstein, K. Dewar, A. Plevneshi, T.B.T. Athey, J.B. Gubbay, M.R. Mulvey, I. Martin, W. Demczuk and N. Fittipaldi. 2018. Canada-wide epidemic of emm74 group A streptococcus invasive disease. Open Forum Infectious Diseases. https://doi.org/10.1093/ofid/ofy085. PMID: 29780850.
Worthington, P., G.J. Tyrrell, K. Choy, L. Eisenbeis, R. Long, and R. Cooper. 2018. Prevalence of latent tuberculosis infection in Syrian refugees to Canada. Canadian Journal of Public Health. 109(1):8-14. https://doi.org/10.17269/s41997-018-0028-7. PMID: 29981073.
Cheng, M.P., I.I. Bogoch, K. Green, A. Plevneshi, W. Rudick, A. Shigayeva, A. McGeer, T.C. Lee and the Toronto Invasive Bacterial Diseases Network (G.J. Tyrrell – member). 2018. Factors associated with 30-day mortality rate in respiratory infections caused by Streptococcus pneumoniae. Clinical Infectious Diseases. 66(8): 1282-1285. PMID: 29140429
Tsang, R., T. Ahmad, S. Tyler, B. Lefebvre, S. Deeks, R. Gilca, L. Hoang, G.J. Tyrrell, P. van Caeseele, G. Van Domselaar and F. Jamieson. 2018. Whole genome typing of the recently emerged Canadian serogroup W Neisseria meningitidis sequence type-11 clonal complex associated with invasive meningococcal disease. International Journal of Infectious Diseases. 2018 Feb 4. 69:55-62. PMID: 29414677.
2017
Madrid L, Seale AC, Kohli-Lynch M, Edmond KM, Lawn JE, Heath PT, Madhi SA, Baker CJ, Bartlett L, Cutland C, Gravett MG, Ip M, Le Doare K, Rubens CE, Saha SK, Sobanjo-Ter Meulen A, Vekemans J, Schrag S; Infant GBS Disease Investigator Group. (members alphabetically: R. Agarwal, A.R. Araujo da Siva, Q. Bassat, J. Berkely, Z. Danjor, S. Dhaded, E. Giannoni, M. Hammoud, K. Le Doare, S.A. Nanduri, C. O’Sullivan, S. Saha, H. Sakata, D.N.B. Santhanam Sridhar, B. Sigauque, G.J. Tyrrell and P. Vinod.). 2017. Infant Group B streptococcal disease incidence and serotypes worldwide: systematic review and meta-analyses. Clinical Infectious Diseases. 2017 Nov 6; 65(suppl_2):S160-S172. PMID: 29117326.
Marrie, T.J., G.J. Tyrrell, S.R. Majumdar and D.T. Eurich. 2017. Risk factors for pneumococcal endocarditis. European Journal of Clinical Microbiology. 37(2): 277-280. PMID: 29067623.
Marrie, T.J., G.J. Tyrrell, S.R. Majumdar and D.T. Eurich. 2017. Rates of, and risk factors for, septic arthritis in patients with invasive pneumococcal disease: prospective cohort study. BMC Infectious Diseases. 2017 Oct 12; 17(1):680. doi: 10.1186/s12879-017-2797-7. PMID: 29025402.
Turvey, S., C. Hui, G.J. Tyrrell and A. Singh. 2017. Brucella suis as a cause of late prosthetic joint infection: a case report and review of the literature. Journal of the Association of Medical Microbiology and Infectious Diseases Canada. Vol.2 (1): DOI: 10.3138/jammi.2.1.010
Tyler, A.D., E. Randall, M. Baikiem K. Antonation, D. Janella, S. Christianson, G.J. Tyrrell, M. Graham, G. Van Domselaar and M.K. Sharma. 2017. Application of whole genome sequence analysis to the study of Mycobacterium tuberculosis in Nunavut, Canada. PLoS One. Oct 5; 12(10):e0185656. doi: 10.1371/journal.pone.0185656. PMID: 28982116.
Marrie, T.J., G.J. Tyrrell, S.R. Majumdar and D.T. Eurich. 2017. The effect of age on the manifestations and outcomes of invasive pneumococcal disease in adults in Northern Alberta. American Journal of Medicine. 131(1): 100.e1-100.e7. PMID: 28803139
Tsang, R.S.W., L. Hoang, G.J. Tyrrell, G. Horsman, P. Van Caeseele, F. Jamieson, B. Lefebvre, D. Haldane, R.R. Gad, G.J. German and G. Zahariadis. 2017. Increase in Neisseria meningitidis serogroup W invasive disease in Canada: 2009-2016. Canada Communicable Disease Reports (CCDR). 43(7/8): 144-149. PMID: 29770081.
Marrie, T.J., G.J. Tyrrell, S.R. Majumdar, and D.T. Eurich. 2017. Concurrent Infection with Hepatitis C and Streptococcus pneumoniae. Emerging Infectious Diseases. 23(7):1118-1123. PMID: 28628455.
Alhhazmi, A, A. Pandey and G.J. Tyrrell. 2017. Identification of the Group B Streptococcus Capsule Type using a Dual Phenotypic/Genotypic Assay. Journal of Clinical Microbiology. 55(9):2637-2650. PMID: 28615470.
Marrie, T.J., G.J. Tyrrell, S.R. Majumdar and D.T. Eurich. 2017. Invasive pneumococcal disease: still lots to learn and a need for standardized data collection instruments. Canadian Respiratory Journal. 2017; 55(0): 2637-2650. PMID: 28424565.
Turvey, S.L., G.J. Tyrrell, C. Hernandez, D. Kabbani, K. Doucette and C. Cervera. 2017. Mycobacterium branderi infection: Case report and literature review of an unusual and difficult-to-treat non-tuberculous mycobacterium. International Journal of Infectious Diseases. 2017 Mar 4. pii: S1201-9712(17)30085-1. doi: 10.1016/j.ijid.2017.03.002. [Epub ahead of print] PMID: 28268125
Tsang, R., M. Shuel, K. Whyte, L. Hoang, G.J. Tyrrell, G. Horsman, J. Wylie, F. Jamieson, B. Lefebvre, D. Haldane, R. Gad, G. German and R. Needle. 2017. Antibiotic susceptibility and molecular analysis of invasive Haemophilus influenzae in Canada, 2007 to 2014. Journal of Antimicrobial Chemotherapy. Dkw565.doi:10.1093/jac/dkw565. On-line: February 1, 2017. PMID: 28137937
Antonation, K., S. Patel, W.J. Trumble, P.P. Poliquin, D. Alexander, L. Hoang, D. Farrell, R. Garceau, D. Haldane, F. Jamieson, R. Marchand, A. McKeen, D. Marcino, S. Theriault, G.J. Tyrrell, G. Zahariadis, N. Zelyas on behalf of the Canadian Public Health Laboratory Network. 2017. Interim laboratory testing guidelines for the detection of Mycobacterium (NTM) infections in post-operative patients exposed to heater-cooler units. Canadian Communicable Diseases Report (CCDR). 43(1): 25-28. PMID: 29770044.
2016
Beatty, J.A., S.R. Majumdar, G.J. Tyrrell, T.J. Marrie, and D.T. Eurich. 2016. Prognostic factors associated with mortality and major in-hospital complications in patients with bacteremic pneumococcal pneumonia: population-based study. Medicine (Baltimore). 95(46):e5179. PMID: 27861340.
Marrie, T.J., G.J. Tyrrell, S.R. Majumdar, and D. Eurich. 2016. Asplenic patients and invasive pneumococcal disease-how bad is it these days? International Journal of Infectious Diseases. 51:27-30. PMID: 27590561.
Beatty, J., S. Majumdar, G.J. Tyrrell, T. Marrie, and D. Eurich. 2016. Current smoking and reduced mortality in bacteremic pneumococcal pneumonia: a population-based cohort study. Chest. 150(3): 652-660. PMID: 27151328.
Lau A., J. Barrie, C. Winter, A. Elamy, G.J. Tyrrell and R. Long. 2016. Chest radiographic patterns and the transmission of tuberculosis: implications for automated systems. PLoS One. 2016 Apr 22; 11(4):e0154032. doi: 10.1371/journal.pone.015403. PMID: 27105337.
Alhhazmi, A, D. Hurteau, G.J. Tyrrell. 2016. Epidemiology of Invasive Group B Streptococcal Disease in Alberta, Canada, 2003-2013. Journal of Clinical Microbiology. 54(7): 1774-1781. PMID: 27098960.
Suresh, S., G.J. Tyrrell, A. Alhhazmi, S. Escoredo and M. Hawkes. 2016. Recurrent sepsis and neuroinvasive disease in a neonate culture positive for a capsular serotype III group B streptococcus hvgA+ strain: a case report. Journal of Medical Microbiology Case Reports. 3(3): e005034. PMID: 28348758.
Miller, R.R., M.G. Langille, V. Montoya, A. Crisan, A. Stefanovic, I. Martin, L. Hoang, D.M. Patrick, M. Romney, G.J. Tyrrell, S.J. Jones, F.S. Brinkman and P. Tang. 2016. Genomic analysis of a serotype 5 Streptococcus pneumoniae outbreak in British Columbia, Canada 2005-2009. Canadian Journal of Infectious Disease and Medical Microbiology. 2016; 2016:5381871. doi: 10.1155/2016/5381871. Epub 2016 Apr 14. PMID: 27366170.
Demczuk, W., I. Martin, G. Van Domselaar, M. Graham, S. Peterson, A. Bharat, B. Lefebvre, V. Allen, L. Hoang, G.J. Tyrrell, G. Horsman, J. Wylie, D. Haldane, C. Archibald, T. Wong and M.R. Mulvey. 2016. Genomic epidemiology and molecular resistance mechanisms of azithromycin resistant Neisseria gonorrhoeae in Canada from 1997 to 2014. 2016 Mar 2. Pii: Journal of Clinical Microbiology.03195-15 [EPUB ahead of print]. PMID: 27366170.
Tsang, R.S.W., A. Li, A. Muller, M. Baikie, K. Whyte, M. Shuel, G.J. Tyrrell, J.A.L. Rotondo, S. Desai and J. Spika. 2016. Laboratory characterization of invasive Haemophilus influenzae isolated from Nunavut, Canada, 2000-2012. International Journal of Circumpolar Health. 75:29798, http://dx.doi.org/10.3402/ijch.v75.29798. PMID: 28156415.
2015
Hamula, C., H. Peng, Z. Wang, G.J. Tyrrell, X-F. Li and X.C. Le. 2015. An improved SELEX technique for selection of DNA aptamers binding to M-type 11 of Streptococcus pyogenes. Methods. 97:51-57. PMID: 26678795.
Shigayeva, A., W. Rudnick, K. Green, G.J. Tyrrell, W. Demczuk, W. Gold, J. Gubbay, F. Jamieson, A. Plevneshi, S. Pong-Porter, S. Richardson, A. McGeer and the Toronto Invasive Diseases Network. 2015. Association of serotype with respiratory presentations of pneumococcal infection, Ontario, Canada, 2003-2011. Vaccine. 34(6): 846-853. PMID: 26602266.
Hamula, C.L.A., H. Peng, Z. Wang, A.M. Newbigging, G.J. Tyrrell, X.F. Li and X.C. Le. 2015. The effects of SELEX conditions on the resultant aptamer pools in the selection of aptamers binding to bacterial cells. Journal of Molecular Evolution. 81(5-6):194-206. PMID: 26538121.
Good, M.F., M. Pandey, M.R. Batzloff and G.J. Tyrrell. 2015. Strategic development of the conserved region of the M protein and other candidates as vaccines to prevent infection with Group A streptococci. Expert Review of Vaccines. 14(11):1459-1470. PMID: 26485214.
Shigayeva, A, W. Rudnick, K. Green, D. Chen, W. Demzcuk, W. Gold, J. Johnstone, I. Kitai, S. Krajden, R. Lovinsky, M. Muller, J. Powis, N. Rau, S. Walmsley, G.J. Tyrrell, A. McGeer. 2015. Invasive pneumococcal disease among immunocompromised persons: implications for vaccination programs. Clinical Infectious Diseases. 2015 Sep 9. PMID: 26354970.
Sawatzky, P., G. Liu, J.R. Dillon, V. Allen, B. Lefebvre, L. Hoang, G.J. Tyrrell, P. van Caeseele, P. Levett, and I. Martin. 2015. Quality assurance for antimicrobial susceptibility testing of Neisseria gonorrhoeae in Canada 2003 to 2012. Journal of Clinical Microbiology. 53(11):3646-3649. PMID: 26338862.
Peterson, S.W., I. Martin, W. Demczuk, A. Bharat, L. Hoang, J. Wylie, V. Allen, B. Lefebvre, G.J. Tyrrell, G. Horsman, D. Haldane, R. Garceau, T. Wong and M.R. Mulvey. 2015. Molecular assay for the detection of ciprofloxacin resistance in Neisseria gonorrhoeae from cultures and clinical nucleic acid amplification test (NAAT) specimens. Journal of Clinical Microbiology. 53(11):3606-3608. PMID: 26292300.
Peterson, S.W., I. Martin, W. Demczuk, A. Bharat, L. Hoang, J. Wylie, V. Allen, B. Lefebvre, G.J. Tyrrell, G. Horsman, D. Haldane, R. Garceau, T. Wong and M. Mulvey. 2015. Molecular assay for the detection of genetic markers associated with decreased susceptibility to cephalosporins in Neisseria gonorrhoeae. Journal of Clinical Microbiology. 53(7):2042-2048. PMID: 25878350.
Gounder, P.P., T. Zulz, S. Desai, F. Stenz, K. Rudolph, R. Tsang, G.J. Tyrrell and M.G. Bruce. 2015. Epidemiology of meningitis caused by Haemophilus influenzae, Neisseria meningitdis and Streptococcus pneumoniae in North American Arctic, 2000-2010. Journal of Infection. 71(2):178-187. PMID: 25864638.
Waye, A., A. Chuck, P. Jacobs, G.J. Tyrrell, J.D. Kellner, V. Remple. 2015. Prevnar 7 childhood immunization program in pneumococcal incidence and resulting impact on health care costs in Alberta (2003-2008). Drugs – Real World Outcomes. 2(2):153-161.
Tsang, R.S., L. Hoang, G.J. Tyrrell, G. Horsman, J. Wylie, F. Jamieson, B. Lefebvre and M. Taha. 2015. Genetic and antigenic characterization of Canadian invasive Neisseria meningitidis serogroup C (MenC) case isolates in the post MenC-conjugate vaccine era, 2009-2013. Journal of Medical Microbiology. 64(Pt2):174-179. PMID: 25587078.
Simmonds, D.K., S. Fathima, L. Chui, M. Lovgren, P. Shook, M. Shuel, G.J. Tyrrell, R. Tsang, S.J. Drews. 2015. Dominance of two genotypes of Bordetella pertussis during a period of increased pertussis activity in Alberta, Canada: January 2012 - August 2012. International Journal for Infectious Diseases. 29:223-225. PMID: 25462185.
Demczuk, W., T. Lynch, I. Martin, G. Van Domselaar, M. Graham, A. Bharat, V. Allen, L. Hoang, B. Lefebvre, G.J. Tyrrell, G. Horsman, D. Haldane, R. Garceau, J. Wylie, T. Wong, and M. Mulvey. 2015. Whole-genome phylogenetic heterogeneity of Neisseria gonorrhoeae with decreased cephalosporin susceptibility collected in Canada between 1989 and 2013. Journal of Clinical Microbiology. 53(1):191-200. PMID: 25378573.
2014
Law, D., J. Zhou, S. Deng, L. Hoang, G.J. Tyrrell, G. Horsman, J. Wylie and R.S. Tsang. 2014. Determination of serotyping antigens, clonal analysis and genetic characterization of the 4CMenB vaccine antigen genes in invasive Neisseria meningitidis from western Canada, 2009 to 2013. Journal of Medical Microbiology. 63(Pt11):1490-1499. PMID: 25165123.
Green, K., A, McGeer, W. Rudnick, S. Pong-Porter, S. Patel, D.E. Low and the Canadian Bacterial Diseases Surveillance Network (G.J. Tyrrell – member). 2014. in vitro activity of new cephalosporins vs Streptococcus pneumoniae from the Canadian bacterial surveillance network: 2008-2011. Current Microbiology. 69(5):763-767. PMID: 25023636.
2013
Demczuk, W., I. Martin, A. Griffith, B. Lefebvre, A. McGeer, M. Lovgren, G.J. Tyrrell, S. Desai, L. Sheeard, H. Adam, M. Gilmour, G. Zhanel. 2013. Serotype distribution of invasive Streptococcus pneumoniae in Canada after the introduction of the 13-valent pneumococcal conjugate vaccine, 2010-2012. Canadian Journal of Microbiology. 59(12):778-788. PMID: 24313450.
Rudick, W., Z. Liu, A. Shigayeva, D. Low, K. Green, A. Plevneshi, R. Devlin, J. Downey, K. Katz, I. Kitai, S. Krajden, K. Ostrowska, D. Richardson, S. Richardson, A. Sarabia, M. Siverman, A. Simor, G.J. Tyrrell, A. McGeer, Toronto Invasive Diseases Network. 2013. Pneumococcal vaccination programs and the burden of invasive pneumococcal disease in Ontario, Canada, 1995-2011. Vaccine. 31(49):5863-5871. PMID: 24099873.
Feikin, D.R., E.W. Kagucia, J. Loo, R. Link-Gelles, M. Puham, T. Cerian, O.S. Levine, C.G. Whitney, K. O’Brien, M.R. Moore and the Serotype Replacement Group (G.J. Tyrrell-member). 2013. Serotype-specific changes in invasive pneumococcal disease after pneumococcal conjugate vaccine introduction – a pooled analysis of multiple surveillance sites. PLoS Med. 10(9):e1001517. PMID: 24086113.
Fittipaldi, N., G.J. Tyrrell, D.E. Low, I. Martin, D. Lin, K.L. Hari and J.M. Musser. 2013. Integrated Whole-Genome Sequencing and Temporospatial Analysis of a Continuing Group A Streptococcus Epidemic. Emerging Microbes and Infection. EPUB. 2,e13. Mar 27, 2013. PMID: 26038455.
Ahmed, R.A., C. Shandro, G.J. Tyrrell, M.K. Sharma, and L.J. Miedzinski. 2013. Safety of injecting insulin through clothes: a case of Mycobacterium immunogenum cutaneous infection and review of the literature. Clinical Diabetes. 31(2):76-78.
Hoefsloot, W., J. van Ingen, C. Andrejak, K. Ängeby, R. Bauriaud, P. Bemer, M.J. Boeree, J. Cacho , E. Chimara, R. Cias, R. Dasa, P.N.R. Dekhuijzen, D. Domingo, F. Drobniewski, J. Esteban, M. Fauville-Dufaux, D.B. Folkvardsen, N. Gibbons, E. Gómez-Mampaso , R. Gonzalez , H. Hoffmann, P.R. Hsueh, A. Indra, T. Jagielski, F. Jamieson, M. Jankovic, J. Keane, W.J. Koh, S. Leao, R. Macedo, T. Mannsåker, T. Marras, J. Maugein, H. Milburn, T. Mlinkó, N. Morcillo, K. Morimoto, D. Papaventis, E. Palenque, M. Paez-Peña, C. Piersimoni, M. Polanová, N. Rastogi, E. Richter, M.J. Ruiz-Serrano, A. Silva, H. Simsek, D. van Soolingen, N. Szabó, R. Thomson, M.T. Tórtola Fernandez, E. Tortoli, S.E. Totten, G.J. Tyrrell, T. Vasankari, M. Villar, R. Walkiewicz, K. Winthrop, D. Wagner for NTM-NET. 2013. The geographic diversity of nontuberculous mycobacteria isolated from pulmonary samples: An NTM-net collaborative study. European Respiratory Journal. 42(6): 1604-1613. PMID: 23598956.
Doucette, K., M. Al-Saif, N. Kneteman, L. Chui, G.J. Tyrrell, D. Kumar and A. Humar. 2013. Donor-derived bacteremia in liver transplant recipients despite antibiotic prophylaxis. American Journal of Transplantation. 13(4):1080-1083. PMID: 23398841.
2012
LeBlanc, J, D. Webster, G.J. Tyrrell and I. Chiu. 2012. Mycobacterium marinum infection from Sea Monkeys. Canadian Journal of Infectious Diseases and Medical Microbiology. 23(4):e106-e108. PMID: 24294280.
Crago, C., C. Ferrato, S.J. Drews, L. Svenson, G.J. Tyrrell and M. Louie. 2012. Prevalence of Staphylococcus aureus in food samples associated with foodborne samples associated with foodborne illness in Alberta, Canada from 2007-2010. Food Microbiology. 32(1):202-205. PMID: 22850394.
Demczuk, W., I. Martin, A. Griffith, B. Lefebvre, A. McGeer, A. Shane, G. Zhanel, G.J. Tyrrell, M. Gilmour, Toronto Invasive Diseases Network, and Canadian Public Health Laboratory network. 2012. Serotype Distribution of invasive Streptococcus pneumoniae in Canada during the introduction of the 13-valent pneumococcal conjugate vaccine, 2010. Canadian Journal of Microbiology. 58(8):1008-1017. PMID: 22827750.
Boone, T.J. and G.J. Tyrrell. 2012. Identification of the Actin and Plasminogen Binding Regions of Group B Streptococcal phosphoglycerate kinase. Journal of Biological Chemistry. 287(34):29035-29044. PMID: 22761440.
Leal, J., O.G. Vanderkooi, D. Church, J. MacDonald, G.J. Tyrrell and J. Kellner. 2012. Eradication of invasive pneumococcal disease (IPD) due to the 7-valent Pneumococcal Conjugate Vaccine (PCV7) serotypes in Calgary, Alberta. Pediatric Infectious Diseases Journal. 31(9):e169-e175. PMID: 22673137.
Tyrrell, G.J., M. Lovgren, S. Garg, L. Chui, T.J. Boone, C. Mangan, D. Patrick, L. Hoang, G. Horsman, P. van Caeseele and T.J. Marrie. 2012. A Streptococcus pneumoniae serotype 5 disease epidemic in western Canada: 2005-2009. Emerging Infectious Diseases. 18(5); 733-740. PMID: 22515944.
Boone, T.J. and G.J. Tyrrell. 2012. Identification of Genes Affecting Expression of Phosphoglycerate Kinase on the Surface of Group B Streptococcus. Canadian Journal of Microbiology. 58:433-441. PMID: 22444251.
Fittipaldi, N.V., S.B. Beres, R.J. Olsen, V. Kapur, P.R. Shea, M.E. Watkins, C. Cantu, D. R. Laucirica, L. Jenkins, A.R Flores, M. Lovgren, G. Spire, C. Ardanuy, J. Linares, D.E. Low, G.J. Tyrrell and J.M. Musser.2012. Full genome dissection of an epidemic of severe invasive disease caused by a hyper virulent, recently emerged clone of group A streptococcus. American Journal of Pathology. 180(4):1522-1534. PMID: 22330677.
Olsen, R.J., D. Laucerica, M.E. Watkins, M. Feske, J. R. Garcia-Bustillos, C. Vu, C. Cantu, S.A. Shelburne III, N. Fittipaldi, M. Kumaraswami, P.R. Shea, A.R. Flores, S. B. Beres, M. Lovgren, G.J. Tyrrell, A. Efstratiou, D.E. Low, C.A. Van Beneden, and J.M. Musser. 2012. Polymorphisms in regulator of protease B (RopB) alter disease phenotype and strain virulence of serotype M3 Group A Streptococcus. Journal of Infectious Diseases. 205(11):1719-1729. PMID: 22262791.
Sahni, V., M. Naus, L. Hoang, G.J. Tyrrell, I. Martin, and D.M. Patrick. 2012. The epidemiology of invasive pneumococcal disease in British Columbia following implementation of an infant immunization program: increases in herd immunity and replacement disease. Canadian Journal of Public Health. 103(1):29-33. PMID: 22338325.
2011
Sharma, M., L. Thibert, P. Chedore, C. Shandro, F. Jamieson, G.J. Tyrrell, S. Christianson, H. Soualhine and J. Wolfe. 2011. A Canadian multicentre laboratory study for standardized second-line antimicrobial susceptibility testing of Mycobacterium tuberculosis. Journal of Clinical Microbiology. 49(12):4112-4116. PMID: 21998413.
Johnstone, J., G.J. Tyrrell, T.J. Marrie, S. Garg, J. Kellner and the SPAT Group. 2011. Streptococcus pneumoniae meningitis in a large Canadian population pre and post introduction of the 7-valent pneumococcal conjugate vaccine. Canadian Journal of Infectious Disease and Medical Microbiology. 22(4):137-141. PMID: 23205025.
Talavlikar, R., B. Meatherill, S. Desai, J. Carson, S. Kuhn, M. Sharma, C. Shandro and G.J. Tyrrell. 2011. Mycobacterium senegalense tissue infection in a child related to fish tank exposure. Canadian Journal of Infectious Disease and Medical Microbiology. 22(3):101-103. PMID: 22942887.
Boone, T.J., C.D. Burnham and G.J. Tyrrell. 2011. Binding of Group B Streptococcal Phosphoglycerate Kinase to Plasminogen and Actin. Microbial Pathogenesis. 51(4):255-261. PMID: 21729749.
Kuster, S.P., A.R. Tuite, J.C. Kwong, A. McGeer, the Toronto Invasive Bacterial Diseases Network (G.J. Tyrrell-member) and D.N. Fisman. 2011. Evaluation of co-seasonality of influenza and invasive pneumococcal disease; results from prospective surveillance. PLoS Medicine. 8(6); e1001042. PMID: 21687693.
Patel, S.N., A. McGeer, R. Melano, G.J. Tyrrell, K. Green, D.R. Pillai and D.E. Low. 2011. Susceptibility of Streptococcus pneumoniae to fluoroquinolones in Canada. Antimicrobial Agents and Chemotherapy 55(8):3703-3708. PMID: 21628545.
Jacobs, S., A. Warman, R. Richardson, W. Yacoub, A. Lau, D. Whittaker, S. Cockburn, G. Verma, J. Boffa, G.J. Tyrrell, D. Kunimoto, J. Manfreda and R. Long. 2011. The tuberculin skin test is unreliable in low risk bacilli calmette-guerin (BCG) – vaccinated school children. Pediatric Infectious Diseases Journal 30(9):754-758. PMID: 21487326.
Marrie, T.J., G.J. Tyrrell, S. Garg, O.G. Vanderkooi. 2011. Factors predicting mortality in invasive pneumococcal disease. Medicine (Baltimore) 90(3):171-179. PMID: 21512414.
Tyrrell, G.J. 2011. The changing epidemiology of Streptococcus pneumoniae serotype 19A. Invited Editorial. Journal of Infectious Diseases. 203(10):1345-1347. PMID: 21398394.
2010
Tyrrell, G.J., M. Lovgren, T. St. Jean, L. Hoang, D. Patrick, G. Horsman, P. van Caeseele, L. E. Sieswerda, A. McGeer, R. A. Laurence, AM. Bourgault and D.E. Low. 2010. Epidemic of group A streptococcus M/emm59 causing invasive disease in Canada. Clinical Infectious Diseases. 51(11):1290-1297. PMID: 21034198.
Olsen, S-R, R. Long, G.J. Tyrrell and D. Kunimoto. 2010. Induced sputum for the diagnosis of pulmonary tuberculosis: is it useful in clinical practice? Canadian Respiratory Journal, 17(4):e81-e84. PMID: 20808978.
Wong, A., T.J. Marrie, S. Garg, J.D. Kellner and G.J. Tyrrell. 2010. Welders are at Increased Risk for Pneumococcal Disease. International Journal of Infectious Disease. 14(9):e796-799. PMID: 20637673.
Chuck, A., P. Jacobs, G.J. Tyrrell and J.D. Kellner. 2010. Pharmaco-economic evaluation of 10 and 13-valent pneumococcal conjugate vaccines. Vaccine. 28(33):5485-5490. PMID: 20554066.
Wong, A., T.J. Marrie, S. Garg, J.D. Kellner, G.J. Tyrrell. 2010. Increased risk of invasive pneumococcal disease in hematologic and solid-organ malignancies. Epidemiology and Infection. 138(12):1804-1810. PMID: 20429967.
Waisman, D.C., G.J. Tyrrell, J.D. Kellner, S. Garg and T.J. Marrie. 2010. Pneumococcal peritonitis – still with us and likely to increase in importance. Canadian Journal of Infectious Diseases and Medical Microbiology 21(1):e23-27. PMID: 21358876.
Beres, S.B., R.K. Carroll, P.S. Shea, I. Sitkiewicz, J. C. Martinez-Gutierrez, D.E. Low, A. McGeer, B. Willey, K. Green, G.J. Tyrrell, T.D. Goldman, M. Feldgarden, B.W. Birren, Y. Fofanov, J. Boos, W.D. Wheaton, C. Honisch and J.M. Musser. 2010. Molecular complexity of successive bacterial epidemics deconvoluted by deep-genome sequencing and systems biology analysis. Proceedings of the National Academy of Sciences (PNAS), 107(9):4371-4376. PMID: 20142485.
Bettinger, J.A., D.W. Scheifele, J.D. Kellner, S.A. Halperin, W. Vaudry, B. Law and G.J. Tyrrell. 2010. The effect of routine vaccination on invasive pneumococcal infections in Canadian children, immunization monitoring program, active 2000-2007. Vaccine. 28(9): 2130-2136. PMID: 20044050.
Liu, Y., C. Wang, G.J. Tyrrell and XF Li. 2010. Production of Shiga-like toxins in viable but nonculturable Escherichia coli O157:H7. Water Research. 44(3):711-718. PMID: 19879621.
2009
Plevneshi, A., T. Svoboda, I. Armstrong, G.J. Tyrrell, A. Miranda, K. Green, A. McGeer, the Toronto Invasive Bacterial Diseases Network. 2009. Invasive Pneumococcal disease in homeless adults in Toronto: five years of population-based surveillance. PLoS One. Sept 29, 4(9):e7255. PMID: 19787070.
Kellner, J.D., O.G. Vanderkooi, J. MacDonald, D.L. Church, G.J. Tyrrell and D. Scheifele. 2009. Changing epidemiology of invasive pneumococcal disease in Canada 1998 to 2007: update from the Calgary Area Streptococcus pneumoniae research (CASPER) study. Clinical Infectious Diseases. 49(2):205-212. PMID: 19508165.
Tyrrell, G.J., M. Lovgren, N. Chui, J. Minion, S. Garg, J.D. Kellner and T.J. Marrie. 2009. Serotypes and antimicrobial susceptibilities of invasive Streptococcus pneumoniae pre and post 7-valent pneumococcal conjugate vaccine introduction in Alberta, Canada, 2000 to 2006. Vaccine. 27(27):3553-3560. PMID: 19464534.
Kunimoto, D., E. Der, A. Beckon, L. Thomas, M. Egedahl, A. Beatch, G. Williams, G.J. Tyrrell, R. Ahmed, N. Brown and R. Long. 2009. Use of the QuantiFERON®-TB GOLD Test to Confirm Latent Tuberculosis Infection in a Canadian Tuberculosis Clinic. International Journal of Tuberculosis and Lung Disease. 13(6):726-730. PMID: 19460248.
Chan, W.W., M. Lovgren and G.J. Tyrrell. 2009. Utility of the PneumoslideTM Test in Identification of Streptococcus pneumoniae in Blood Cultures and its Relation to Capsular Serotype. Journal of Clinical Microbiology, 47(5):1559-1561. PMID: 19321721.
Liu, Y., C. Wang, G.J. Tyrrell, S.E. Hrudey and X-F. Li. 2009. Induction of Escherichia coli O157:H7 into the viable but non-culturable state by chloraminated water and river water, and subsequent resuscitation. Environmental Microbiology Reports. 1(2):155-161. PMID: 23765746.
Pang, X., B.E. Lee, G.J. Tyrrell and J.K. Preiksaitis. 2009. Epidemiology and genotype analysis of Sapovirus in gastroenteritis outbreaks in Alberta, 2004-2007. Journal of Infectious Diseases. 199(4):547-551. PMID: 19099483.
2008
Lam, M., R. Verity, G.J. Tyrrell, R. Arndt, J. Nigrin and S.E. Forgie. 2008. Gram-negative bacteremia and asplenia in a well 15 year old. Canadian Journal of Infectious Diseases and Medical Microbiology. 19(6):391-392. PMID: 19436566.
Kellner, J.D., D. Scheifele, O. G. Vanderkooi, J. Macdonald, D. L. Church and G.J. Tyrrell. 2008. Effects of Routine Infant Vaccination with the 7-Valent Pneumococcal Conjugate Vaccine on Nasopharyngeal Colonization with Streptococcus pneumoniae in Children in Calgary, Canada. Pediatric Infectious Disease Journal, 27(6):526-532. PMID: 18458650.
Chui, L., T. Chiu, J. Kakulphimp and G.J. Tyrrell. 2008. A comparison of three real time PCR assays for the confirmation of Neisseria gonorrhoeae following Roche COBAS AMPLICOR Neisseria gonorrhoeae detection. Clinical Microbiology and Infection, 14(5):473-479. PMID: 18294244.
Dawar, M., B. Russell, K. McClean, P. Levett, G.J. Tyrrell and J. Irvine. 2008. A case of necrotizing fasciitis due to Streptococcus pneumoniaeserotype 5 in Saskatchewan. Canadian Journal of Infectious Diseases and Medical Microbiology, 19(1):69-71. PMID: 19145265.
Kumar, D., A. Humar, A. Plevneshi, D. Siegal, N. Franke, K. Green, A. McGeer, and the Toronto Invasive Bacterial Disease Network (G.J. Tyrrell – member). 2008. Invasive pneumococcal disease in adult hematopoietic stem cell transplant recipients: a decade of prospective population-based surveillance. Bone Marrow Transplantation. 41:743-747. PMID: 18176614.
Bruce, M.G., S.L. Deeks, T. Zulz, D. Bruden, C. Navarro, M. Lovgren, C. Palacios, C. Case, C. Hemsley, T. Hennessy, A. Corriveau, B. Larke, I. Sobel, M. Lovgren, C. Debyle, R. Tsang, A. Parkinson and the International Circumpolar Surveillance Hia Working Group (G.J. Tyrrell – member). 2008. Epidemiology of Haemophilus influenzae serotype a, North American Arctic, 2000-2005. Emerging Infectious Diseases. 14:48-55. PMID: 18258076.
Bruce, M.G., S.L. Deeks, T. Zulz, D. Bruden, C. Navarro, M. Lovgren, L. Jette, K. Kristinsson, G. Sigmundsdottir, K. B. Jensen, O. Lovoll, J.P. Nuorti, E. Herva, A. Nystedt, A. Sjosted, A. Koch, T.W. Hennessy, A. Parkinson and the International Circumpolar Surveillance System for Invasive Pneumococcal Disease Working Group (G.J. Tyrrell – member). 2008. International Circumpolar Surveillance System for Invasive Pneumococcal Disease, 1999-2005. Emerging Infectious Diseases. 14:25-33. PMID: 18258073.
Degani, N., C. Navarro, S.L. Deeks, M. Lovgren and the Canadian International Circumpolar Surveillance Working Group (G.J. Tyrrell – member). 2008. Invasive Bacterial Diseases in Northern Canada. Emerging Infectious Diseases. 14:34-40. PMID: 18258074.
Burgess, T., A.F. Hirschfeld, G.J. Tyrrell, J.A. Bettinger and S.E. Turvey. 2008. Commonly invasive serotypes of Streptococcus pneumoniaetrigger a reduced innate immune response compared with serotypes rarely responsible for invasive infection. FEMS Immunology and Medical Microbiology. 53(1):136-139. PMID: 18248437.
Winters, M., D. Patrick, F. Marra, J. Buxton, M. Chong, J. Isaac-Renton, C. Shaw, G.J. Tyrrell, M. Lovgren, and S. Paulus. 2008. Epidemiology of invasive pneumococcal disease in B.C. during the introduction of conjugated pneumococcal vaccine. Canadian Journal of Public Health. 99(1):57-61. PMID: 18435393.
Shahidi, N., J. Dhaliwal, G.J. Tyrrell, L. Hoang and D. Patrick. 2008. Trends in incidence of invasive pneumococcal disease following introduction of the universal infant immunization program in British Columbia, 2002-2006. BC Medical Journal. 50:18-21
2007
Lovgren, M., J. A. Talbot, E. Castañeda, M. C. Brandileone, G. Echániz-Avilés, M. Hortal, M. Regueira, I. Heitmann, J. L. di Fabio and the SIREVA Study Group (G.J. Tyrrell-member). 2007. The SIREVA Project 1993-2005: The Evolution of an International EQA Model. Journal of Clinical Microbiology. 45:3184-3190. PMID: 17687007.
Neal, S., B. Beall, K. Ekelund, B. Henriques-Normark, A. Jasir, D. Johnson, E. Kaplan, M. Lovgren, R. Reinert, members of the International Streptococcus Reference Laboratories (G.J. Tyrrell – member) and A. Efstratiou. 2007. International Quality Assurance for the Characterisation of Streptococcus pyogenes. Journal of Clinical Microbiology. 45:1175-1179. PMID: 17267628.
Burnham, C.D., S. Shokoples, and G.J. Tyrrell. 2007. Invasion of HeLa cells by group B streptococcus requires the phosphoinositide-3-kinase signaling pathway and modulates phosphorylation of host-cell Akt and glycogen synthase kinase-3. Microbiology-SGM. 153(Pt12):4240-4252. PMID: 18048937.
Flavelle, S., G.J. Tyrrell and S.E. Forgie. 2007. A serious bloodstream infection in an infant. Canadian Journal of Infectious Diseases and Medical Microbiology. 18(5):311-312.
Daneman, N., K.A. Green, D.E. Low, A.E. Simor, B. Willey, B. Schwartz, B. Toye, P. Jessamine, G.J. Tyrrell, S. Krajden, L. Ramage, D. Rose, R. Schertzberg, D. Bragg, A. McGeer, and the Ontario Group A Streptococcal Study Group. 2007. Surveillance for hospital outbreaks of invasive group A streptococcal infections in Ontario, Canada, 1992-2000. Annals of Internal Medicine. 147(4):234-241. PMID: 17709757.
Webster, D., L. Chui, G.J. Tyrrell and T.J. Marrie. 2007. Healthcare-associated Staphylococcus aureus pneumonia. Canadian Journal of Infectious Diseases and Medical Microbiology. 18(3):181-188. PMID: 18923721.
Bjornson, G., D. W. Scheifle, J. Bettinger, D. Patrick, L. Gustafson, P. Daly and G.J. Tyrrell. 2007. Effectiveness of pneumococcal conjugate vaccine in greater Vancouver, Canada: 2004-2005. Pediatric Infectious Diseases Journal. 26(6):540-542. PMID: 17529875.
Burnham, C.D., S. Shokoples and G.J. Tyrrell. 2007. Rac1, RhoA and Cdc42 participate in HeLa cell invasion by group B streptococcus. FEMS Microbiology Letters. 272(1):8-14. PMID: 17517067.
Marra, F., D.L. Monnet, D.M. Patrick, M. Chong, C. Brandt, M. Winters, M. Kaltoft, G.J. Tyrrell, M. Lovgren, W.R. Bowie. 2007. A comparison of antibiotic use in children between Canada and Denmark. Annals of Pharmacotherapy. 41(4):659-666. PMID: 17374628.
Bettinger, J.A., D.W. Scheifle, S. Halperin, J.D. Kellner, G.J. Tyrrell and Members of the Canadian Paediatrics Society’s Immunization Monitoring Program, Active (IMPACT). 2007. Invasive pneumococcal infections in Canadian children, 1998-2003: Implications for vaccine programs. Canadian Journal of Public Health. 98(2):111-115. PMID: 17441533.
2006
Wetsch, N., K. Somani, G.J. Tyrrell, C. Gelbhart, R.J. Bailey and D.E. Taylor. 2006. Campylobacter curvus associated hepatic abscesses: A case report. Journal of Clinical Microbiology. 44(5):1909-1911. PMID: 16672438.
Jayaraman, J., A.E. Singh, N. Yiannakoulias, J. Gratrix, B. Anderson, M. Johnson, L. Svenson, B. Kress, G.J. Tyrrell, and T. Wong. 2006. Sub-regional variations in the epidemiology of Neisseria gonorrhea in a large urban region in Alberta, Canada: results from spatial analyses using routinely collected surveillance data. Canada Communicable Disease Report 32(4):29-38.
Anderson, H., L. Honish, G. Taylor, M. Johnson, C. Tovstiuk, E.A, Fanning, G.J. Tyrrell, R. Rennie, J. Jaipaul, C. Sand and S. Probert. 2006. Histoplasmosis cluster, Golf Course, Canada. Emerging Infectious Diseases. 12(1):163-165. PMID: 16494738.
Public Health Agency of Canada Invasive Group A Streptococcus Working Group (G.J. Tyrrell - member). 2006. Guidelines for the Prevention and Control of Invasive Group A Streptococcal Disease. Canada Communicable Disease Report 32S2:1-26.
2005
Kellner, J.D., D.L. Church, J. MacDonald, G.J. Tyrrell and D. Scheifle. 2005. Progress in the Prevention of Pneumococcal Infection: The Calgary area Streptococcus pneumoniae epidemiology research (CASPER) study. Canadian Medical Association Journal (CMAJ). 173(10):1149-1151. PMID: 16275962.
Sikora, C., J. Speilman, K. Macdonald, G.J. Tyrrell and J.M. Embil. 2005. Necrotizing fasciitis resulting from human bites: A report of two cases of disease caused by Group A streptococci. Canadian Journal of Infectious Diseases and Medical Microbiology. 16(4):221-224. PMID: 18159548.
Anderson, H., G. Taylor, E.A. Fanning, L. Honish, M. Johnson, J. Jaipaul, S. Probert, C. Tovstiuk, G.J. Tyrrell, R. Rennie, and C. Sand. 2005. Locally-acquired histoplasmosis cluster, Alberta, 2003. Canada Communicable Disease Report. 31(24):1-3.
Vanderkooi, O.G., D.E. Low, K. Green, J.E. Powis, A. McGeer and the Toronto Invasive Bacterial Disease Network (G.J. Tyrrell–member). 2005. Predicting Antimicrobial Resistance in Invasive Pneumococcal Infections. Clinical Infectious Disease, 40:1288-1297. PMID: 15825031.
Daneman, N., A. McGeer, D. E. Low, G.J. Tyrrell, A.E. Simor, M. McArthur, B. Schwartz, P. Jessamine, R. Croxford, K.A. Green, Ontario Group A Streptococcal Study Group. 2005. Hospital-acquired invasive group A streptococcal infections in Ontario, Canada, 1992-2000. Clinical Infectious Diseases. 41(3):334-342. PMID: 16007530.
Honish, L., N. Hislop, I. Zazulak, L. Chui and G.J. Tyrrell. 2005. Restaurant Food-handler-Associated Outbreak of Salmonella Heidelberg Gastroenteritis Identified by Calls to a Local Telehealth Service – Edmonton, Alberta, 2004. Canada Communicable Disease Report, 31(10):1-5.
Burnham, C.D., S. E. Shokoples and G.J. Tyrrell. 2005. Phosphoglycerate Kinase Inhibits Epithelial Cell Invasion by Group B Streptococci. Microbial Pathogenesis. 38(5-6):189-200. PMID: 15925270.
Shariatzadeh, M.R., J.Q. Huang, G.J. Tyrrell, M.M. Johnson and T.J. Marrie. 2005. Bacteremic pneumococcal pneumonia: A prospective study in Edmonton and neighbouring municipalities. Medicine. 84(3):147-161. PMID: 15879905.
Tyrrell, G.J., M. Lovgren, B. Kress and K. Grimsrud. 2005. Invasive Group A streptococcal disease in Alberta, Canada, 2000-2002. Journal of Clinical Microbiology. 43(4):1678-1683. PMID: 15814984.
Tyrrell, G.J., M. Lovgren, B. Kress and K. Grimsrud. 2005. Varicella Associated Invasive Group A streptococcal disease in Alberta, Canada, 2000-2002. Clinical Infectious Diseases. 40(7):1055-1057. PMID: 15825001.
2003
Ng, L., I. Martin, A. Lau and the National Gonococcal Surveillance Program Members (G.J. Tyrrell–member). 2003. Trends of Chromosomal-Mediated Resistance in Neisseria gonorrhoeae in Canada. Journal of Sexually Transmitted Diseases, 30:896-900. PMID: 14646637.
Burnham, C.D. and G.J. Tyrrell. 2003. Virulence Factors of Group B Streptococcus. Review. Reviews in Medical Microbiology, 14(4):109-118.
Vanderkooi, O.G., J.D. Kellner, A.W. Wade, T. Jadavji, J.P. Midgley, T. Louie and G.J. Tyrrell. 2003. Invasive Streptococcus pneumoniae infection causing haemolytic uremic syndrome in children: two recent cases. Canadian Journal of Infectious Diseases and Medical Microbiology. 14:339-343.
Smith, A., A. Li, O. Tolomeo, G.J. Tyrrell, F. Jamieson and D. Fisman. 2003. Mass antibiotic treatment for Group A streptococcus in two-long term care facilities. Emerging Infectious Diseases. 9(10):1260-1265. PMID: 14609461.
Facklam, R.R., M. Lovgren, P. L. Shewmaker and G.J. Tyrrell. 2003. Phenotypic Description and antimicrobial susceptibilities of Aerococcus sanguicola from human clinical samples. Journal of Clinical Microbiology. 41(6):2587-2592. PMID: 12791884.
Desai, T.R, G.J. Tyrrell, T. Ng and W.H. Finlay. 2003. In vitro evaluation of nebulization properties, antimicrobial activity and regional airway surface liquid concentration of liposomal Polymyxin B sulfate. Pharmaceutical Research. 20(3):442-447. PMID: 12669966.
2002
Tyrrell, G.J., A. Kennedy, S.E. Shokoples and R. Sherburne. 2002. Binding and Invasion of HeLa and MRC-5 Cells by Streptococcus agalactiae. Microbiology-SGM. 148(Pt12):3921-3931. PMID: 12480896.
Tyrrell, G.J., M. Lovgren, B. Forwick, N. P. Hoe, J.M. Musser and J.A. Talbot. 2002. M Types of Group A streptococci isolates submitted to the National Centre for Streptococcus (Canada): 1993-1999. Journal of Clinical Microbiology. 40(12):4466-4471. PMID: 12454137.
Tyrrell, G.J., L. Chui, M. Johnson, N. Chang, R. Rennie, J. Talbot and the Edmonton Meningococcal Study Group. 2002. Outbreak of Neisseria meningitidis in Edmonton, Alberta. Emerging Infectious Diseases. 8(5):519-521. PMID: 11996690.
Tyrrell, G.J., L. Turnbull, J. Lefebrve, L. Teixeria, R.R. Facklam and M. Lovgren. 2002. Enterococcus gilvus sp. nov., and Enterococcus pallenssp. nov., isolated from human clinical specimens. Journal of Clinical Microbiology. 40(4):1140-1145. PMID: 11923322.
Facklam, R.R., D. Martin, M. Lovgren, D. Johnson, A. Efstratiou, T. Thompson, S. Gowan, P. Kriz, G.J. Tyrrell, E. Kaplan, B. Beall. 2002. Extension of the Lancefield classification scheme for Group A streptococci by addition of 22 new M protein gene sequence types from clinical isolates: emm103 to emm124. Clinical Infectious Diseases. 34(1):28-38. PMID: 11731942.
2001
Davies, H.D., S. Raj, C. Adair, J. Robinson, A. McGeer and the Alberta GBS Study Group (G.J. Tyrrell-member). 2001. Population-based active surveillance for neonatal group B streptococcal infections in Alberta, Canada: implications for vaccine formulation. Paediatric Infectious Diseases. 20:879-884. PMID: 11734768.
Davies, H.D., C. Adair, A. McGeer, D. Ma, S. Robertson, M. Mucenski, L. Kowalsky, G.J. Tyrrell and C.J. Baker. 2001. Antibodies to Capsular Polysaccharides of Group B Streptococcus in Pregnant Canadian Women: Relationship to Colonization Status and Infection in the Neonate. Journal of Infectious Diseases. 184:285-291. PMID: 11443553.
Kuhn, S.M., J. Preiksaitis, G.J. Tyrrell, T. Jadavji, D. Church and H.D. Davies. 2001. “Evaluation of potential Factors Contributing to Microbiological Treatment Failure in Streptococcus pyogenes Pharyngitis”. Canadian Journal of Infectious Diseases and Medical Microbiology. 12:33-39. PMID:18159315.
2000
Goh, S.H., R.R. Facklam, M. Chang, E.C. Burns, G.J. Tyrrell, J.E. Hill, D. Chan, C. He, T. Rahim, C. Shaw and S.M. Hemmingsen. 2000. Identification of Enterococcus species and phenotypically similar Lactococcus and Vagococcus species by reverse checkerboard hybridization to chaperonin 60 gene sequences. Journal of Clinical Microbiology. 38(11):3953-3959. PMID: 11060051.
Tyrrell, G.J., L. Senzilet, J. Spika, D. Kertesz, J. Talbot, M. Alagartnam, M. Lovgren and the Sentinel Health Surveillance System Site Coordinators. 2000. “Invasive Disease Due to Group B Streptococcal Infection in Adults: Results from a Canadian Population-Based Active Surveillance Study – 1996”. Journal of Infectious Diseases. 182(1):168-173. PMID: 10882594.
Beall, B., G. Gherardi, M. Lovgren, R.R. Facklam, B.A. Forwick and G.J. Tyrrell. 2000. “emm and sof gene sequence variation in relation to serological typing of opacity-factor-positive group A streptococci” Microbiology-SGM. 146(Pt5):1195-1209. PMID: 10832648.
1999
Zanella, R.C., F. Valdetaro, M. Lovgren, G.J. Tyrrell, S. Bokermann, S.C.G. Almeida, V.S.D. Vieira, M. C. Brandileone. 1999. First Confirmed Case of a Vancomycin-Resistant Enterococcus faecium with a vanA Phenotype from Brazil: Isolation from a Meningitis Case in Sao Paulo. Microbial Drug Resistance. 5:159-162. PMID: 10432277.
Johnston, L., L. Chui, N. Chang, S. Macdonald, M. Mackenzie, W. Kennedy, D. Haldane, R. Bethune, G. Taylor and G.J. Tyrrell. 1999. Cross Canada Spread of MRSA via Transplant Organs. Clinical Infectious Diseases. 29(4):819-23. PMID: 10589896.
Facklam, R., B. Beall, A. Efstratiou, V. Fischetti, D. Johnson, E. Kaplan, P. Kriz, M. Lovgren, D. Martin, B. Schwartz, A. Totolian, D. Bessen, S. Hollingshead, F. Rubin, J. Scott and G.J. Tyrrell. 1999. emm Typing and Validation of Provisional M-Types for Group A Streptococci. Emerging Infectious Diseases. 5(2):247-253. PMID: 10221877.
1997
Mackinnon, M., M. Drebot and G.J. Tyrrell. 1997. “Identification and Characterization of IS1476, an Insertion Sequence-like Element that Disrupts VanY Function in a Vancomycin Resistant Enterococcus faecium.” Antimicrobial Agents and Chemotherapy. 41(8):1805-1807. PMID: 9257766.
Tyrrell, G.J., R. Bethune, B. Willey and D.E. Low. 1997. “Species Identification of Enterococci via Intergenic Ribosomal PCR.” Journal of Clinical Microbiology. 35(5):1054-1060. PMID: 9114380.
1993
Boyd, B., G.J. Tyrrell, M. Maloney, C. Gyles, J.L. Brunton and C.A. Lingwood. 1993. “Alteration of the Glycolipid Binding Specificity of the Pig Oedema Disease Toxin from Globotetraosyl to Globotriaosyl Ceramide Alters In vivo Tissue Targeting and Results in a Verotoxin 1-like Disease in Pigs.” Journal of Experimental Medicine. 177(6):1745-1753. PMID: 8496689.
1992
Stein, P., A. Boodhoo, G.J. Tyrrell, J.L. Brunton and R.J. Read. 1992. “Crystal Structure of the Cell-binding B Oligomer of Verotoxin-1 from E. coli.” Nature. 355(6362):748-750. PMID: 1741063.
Tyrrell, G.J., K. Ramotar, B.W. Toye, B. Boyd, C.A. Lingwood and J.L. Brunton. 1992. “Alteration of the Carbohydrate Binding Specificity of Verotoxins From gal(alpha)1-4 to GalNac(beta)1-3gal and vice versa by Site-Directed mutagenesis of the Binding Subunit.” Proceedings of the National Academy of Sciences (PNAS). 89(2):524-528. PMID: 1731324.
1990
Ramotar, K., B. Boyd, G.J. Tyrrell, J. Gariepy, C.A. Lingwood and J.L. Brunton. December 15, 1990. “Characterization of Shiga-like Toxin I B Subunit Purified from Overproducing Clones of the SLT-I B Cistron.” Biochemical Journal. 272(3):805-811. PMID: 2268304.
1989
Tyrrell, G.J., M.S. Peppler, R.A. Bonnah, C. Clark, P. Chong and G.D. Armstrong. 1989. “Lectin-Like Properties of Pertussis Toxin.” Infection and Immunity. 57(6):1854-1857. PMID: 2722243.
Publications
2019
Dey, R., H. Mount, A.W. Ensminger, G.J. Tyrrell, L.P Ward, and N.J. Ashbolt. 2019. Isolation of Legionella pneumophila by coculture with local ameba, Canada. Emerging Infectious Diseases. 25(11): 2104-2107. PMID: 31625866.
Pandey, M., A. Calcutt, V. Ozberk, M. Croxen, J. Powell, E. Langshaw, J. Mills, F. Jen, M. Jennings, J. Robson, G.J. Tyrrell and M. Good. 2019. Antibodies to the conserved region of the M protein and a streptococcal super antigen cooperatively resolve toxic shock-like syndrome in HLA humanized mice. Science Advances. http://advances.sciencemag.org/content/5/9/eaax3013. PMID: 31517054.
Tsang, R.S.W., L. Hoang, G.J. Tyrrell, J. Minion, P. Van Caeseele, J. Kus, B. Lefebvre, D. Haldane, R. Garceau, G. German, G. Zahariadis and B. Hanley. 2019. Continued increase in invasive meningococcal disease due to the ST-11 serogroup W Neisseria meningitidis in Canada, 2016-2018. Canada Communicable Disease Reports. 45(6):164-169. PMID: 31285709.
Lau, D., R. Cooper, J. Chen, V. Sim, J. McCombe, G.J. Tyrrell, R. Bhargava, B. Adam, E. Chapman, M. Croxen, C. Garady, K. Antonation, F. Landeghem, S. Ip, L. Saxinger. 2019. Mycobacterium chimaera encephalitis post-cardiac surgery: a new syndrome. Clinical Infectious Disease. 70(4): 692-695. PMID: 31247065.
Tsang, R.S.W., T. Ahmad, F. Jamieson and G.J. Tyrrell. 2019. WGS analysis of a penicillin-resistant Neisseria meningitidis strain containing a chromosomal ROB-1 β-lactamase gene. Journal of Antimicrobial Chemotherapy. 74(1): 22-28. PMID: 30295754.
2018
Tyrrell, G.J., S. Fathima, J. Kakulphimp and C. Bell. 2018. Increasing rates of Invasive Group A streptococcal disease in Alberta, Canada; 2003-2017. Open Forum Infectious Diseases. Jul 20; 5(8):ofy177. doi: 10.1093/ofid/ofy177. eCollection 2018 Aug. PMID: 30109241.
Alhhazmi, A, and G.J. Tyrrell. 2018. Phenotypic and molecular analysis of nontypeable Group B streptococci: identification of cps2a and hybrid cps2a/cps5 Group B streptococcal capsule gene clusters. Emerging Microbes and Infection. 2018 Aug 8; 7(1):137. doi: 10.1038/s41426-018-0138-6. PMID: 30087323.
Doroshenko, A., C. Pepperell, C. Heffernan, M.L Egedahl, T. Mortimer, T. Smith, T. Mortimer, H.E. Bussan, G.J. Tyrrell, R. Long. 2018. Epidemiological and genomic determinates of tuberculosis outbreaks in First Nations communities in Alberta, Canada. BMC Medicine. 16(1): 128 doi: 10.1186/s12916-018-1112-9. PMID: 30086755.
Demczuk, W., I. Martin, S. Desai, A. Griffith, B. Lefebvre, A. McGeer, G.J. Tyrrell, G. Zhanel, J. Gubbay, L. Hoang, P. Levett, P. van Caeseele, R. Raafat Gad, D. Haldane, G. Zahariadis, G. German, J. Daley Bernier, L. Strudwick and M.R. Mulvey. 2018. Serotype distribution of invasive Streptococcus pneumoniae in adults 65 years of age and over after the introduction of childhood 13-valent pneumococcal conjugate vaccination programs in Canada, 2010-2016. Vaccine. 36(3): 4701-4707. PMID: 29937245.
Sander, M.A., J.L. Isaac-Renton, G.J. Tyrrell. 2018. Cutaneous nontuberculous mycobacterial infections in Alberta, Canada: An epidemiologic study, and review. Journal of Cutaneous Medicine and Surgery. 22(5): 479-483. PMID: 29772918.
Marrie, T.J., G.J. Tyrrell, S.R. Majumdar and D.T. Eurich. 2018. Invasive Pneumococcal Disease in Northern Alberta, not a Red Queen but a Dark Horse. Vaccine. 2018 36(21): 2985-2990. PMID: 29615595.
Teatero, S., A. McGeer, G.J. Tyrrell, L. Hoang, H. Smadi, M. Domingo, P. Levett, M. Finkelstein, K. Dewar, A. Plevneshi, T.B.T. Athey, J.B. Gubbay, M.R. Mulvey, I. Martin, W. Demczuk and N. Fittipaldi. 2018. Canada-wide epidemic of emm74 group A streptococcus invasive disease. Open Forum Infectious Diseases. https://doi.org/10.1093/ofid/ofy085. PMID: 29780850.
Worthington, P., G.J. Tyrrell, K. Choy, L. Eisenbeis, R. Long, and R. Cooper. 2018. Prevalence of latent tuberculosis infection in Syrian refugees to Canada. Canadian Journal of Public Health. 109(1):8-14. https://doi.org/10.17269/s41997-018-0028-7. PMID: 29981073.
Cheng, M.P., I.I. Bogoch, K. Green, A. Plevneshi, W. Rudick, A. Shigayeva, A. McGeer, T.C. Lee and the Toronto Invasive Bacterial Diseases Network (G.J. Tyrrell – member). 2018. Factors associated with 30-day mortality rate in respiratory infections caused by Streptococcus pneumoniae. Clinical Infectious Diseases. 66(8): 1282-1285. PMID: 29140429
Tsang, R., T. Ahmad, S. Tyler, B. Lefebvre, S. Deeks, R. Gilca, L. Hoang, G.J. Tyrrell, P. van Caeseele, G. Van Domselaar and F. Jamieson. 2018. Whole genome typing of the recently emerged Canadian serogroup W Neisseria meningitidis sequence type-11 clonal complex associated with invasive meningococcal disease. International Journal of Infectious Diseases. 2018 Feb 4. 69:55-62. PMID: 29414677.
2017
Madrid L, Seale AC, Kohli-Lynch M, Edmond KM, Lawn JE, Heath PT, Madhi SA, Baker CJ, Bartlett L, Cutland C, Gravett MG, Ip M, Le Doare K, Rubens CE, Saha SK, Sobanjo-Ter Meulen A, Vekemans J, Schrag S; Infant GBS Disease Investigator Group. (members alphabetically: R. Agarwal, A.R. Araujo da Siva, Q. Bassat, J. Berkely, Z. Danjor, S. Dhaded, E. Giannoni, M. Hammoud, K. Le Doare, S.A. Nanduri, C. O’Sullivan, S. Saha, H. Sakata, D.N.B. Santhanam Sridhar, B. Sigauque, G.J. Tyrrell and P. Vinod.). 2017. Infant Group B streptococcal disease incidence and serotypes worldwide: systematic review and meta-analyses. Clinical Infectious Diseases. 2017 Nov 6; 65(suppl_2):S160-S172. PMID: 29117326.
Marrie, T.J., G.J. Tyrrell, S.R. Majumdar and D.T. Eurich. 2017. Risk factors for pneumococcal endocarditis. European Journal of Clinical Microbiology. 37(2): 277-280. PMID: 29067623.
Marrie, T.J., G.J. Tyrrell, S.R. Majumdar and D.T. Eurich. 2017. Rates of, and risk factors for, septic arthritis in patients with invasive pneumococcal disease: prospective cohort study. BMC Infectious Diseases. 2017 Oct 12; 17(1):680. doi: 10.1186/s12879-017-2797-7. PMID: 29025402.
Turvey, S., C. Hui, G.J. Tyrrell and A. Singh. 2017. Brucella suis as a cause of late prosthetic joint infection: a case report and review of the literature. Journal of the Association of Medical Microbiology and Infectious Diseases Canada. Vol.2 (1): DOI: 10.3138/jammi.2.1.010
Tyler, A.D., E. Randall, M. Baikiem K. Antonation, D. Janella, S. Christianson, G.J. Tyrrell, M. Graham, G. Van Domselaar and M.K. Sharma. 2017. Application of whole genome sequence analysis to the study of Mycobacterium tuberculosis in Nunavut, Canada. PLoS One. Oct 5; 12(10):e0185656. doi: 10.1371/journal.pone.0185656. PMID: 28982116.
Marrie, T.J., G.J. Tyrrell, S.R. Majumdar and D.T. Eurich. 2017. The effect of age on the manifestations and outcomes of invasive pneumococcal disease in adults in Northern Alberta. American Journal of Medicine. 131(1): 100.e1-100.e7. PMID: 28803139
Tsang, R.S.W., L. Hoang, G.J. Tyrrell, G. Horsman, P. Van Caeseele, F. Jamieson, B. Lefebvre, D. Haldane, R.R. Gad, G.J. German and G. Zahariadis. 2017. Increase in Neisseria meningitidis serogroup W invasive disease in Canada: 2009-2016. Canada Communicable Disease Reports (CCDR). 43(7/8): 144-149. PMID: 29770081.
Marrie, T.J., G.J. Tyrrell, S.R. Majumdar, and D.T. Eurich. 2017. Concurrent Infection with Hepatitis C and Streptococcus pneumoniae. Emerging Infectious Diseases. 23(7):1118-1123. PMID: 28628455.
Alhhazmi, A, A. Pandey and G.J. Tyrrell. 2017. Identification of the Group B Streptococcus Capsule Type using a Dual Phenotypic/Genotypic Assay. Journal of Clinical Microbiology. 55(9):2637-2650. PMID: 28615470.
Marrie, T.J., G.J. Tyrrell, S.R. Majumdar and D.T. Eurich. 2017. Invasive pneumococcal disease: still lots to learn and a need for standardized data collection instruments. Canadian Respiratory Journal. 2017; 55(0): 2637-2650. PMID: 28424565.
Turvey, S.L., G.J. Tyrrell, C. Hernandez, D. Kabbani, K. Doucette and C. Cervera. 2017. Mycobacterium branderi infection: Case report and literature review of an unusual and difficult-to-treat non-tuberculous mycobacterium. International Journal of Infectious Diseases. 2017 Mar 4. pii: S1201-9712(17)30085-1. doi: 10.1016/j.ijid.2017.03.002. [Epub ahead of print] PMID: 28268125
Tsang, R., M. Shuel, K. Whyte, L. Hoang, G.J. Tyrrell, G. Horsman, J. Wylie, F. Jamieson, B. Lefebvre, D. Haldane, R. Gad, G. German and R. Needle. 2017. Antibiotic susceptibility and molecular analysis of invasive Haemophilus influenzae in Canada, 2007 to 2014. Journal of Antimicrobial Chemotherapy. Dkw565.doi:10.1093/jac/dkw565. On-line: February 1, 2017. PMID: 28137937
Antonation, K., S. Patel, W.J. Trumble, P.P. Poliquin, D. Alexander, L. Hoang, D. Farrell, R. Garceau, D. Haldane, F. Jamieson, R. Marchand, A. McKeen, D. Marcino, S. Theriault, G.J. Tyrrell, G. Zahariadis, N. Zelyas on behalf of the Canadian Public Health Laboratory Network. 2017. Interim laboratory testing guidelines for the detection of Mycobacterium (NTM) infections in post-operative patients exposed to heater-cooler units. Canadian Communicable Diseases Report (CCDR). 43(1): 25-28. PMID: 29770044.
2016
Beatty, J.A., S.R. Majumdar, G.J. Tyrrell, T.J. Marrie, and D.T. Eurich. 2016. Prognostic factors associated with mortality and major in-hospital complications in patients with bacteremic pneumococcal pneumonia: population-based study. Medicine (Baltimore). 95(46):e5179. PMID: 27861340.
Marrie, T.J., G.J. Tyrrell, S.R. Majumdar, and D. Eurich. 2016. Asplenic patients and invasive pneumococcal disease-how bad is it these days? International Journal of Infectious Diseases. 51:27-30. PMID: 27590561.
Beatty, J., S. Majumdar, G.J. Tyrrell, T. Marrie, and D. Eurich. 2016. Current smoking and reduced mortality in bacteremic pneumococcal pneumonia: a population-based cohort study. Chest. 150(3): 652-660. PMID: 27151328.
Lau A., J. Barrie, C. Winter, A. Elamy, G.J. Tyrrell and R. Long. 2016. Chest radiographic patterns and the transmission of tuberculosis: implications for automated systems. PLoS One. 2016 Apr 22; 11(4):e0154032. doi: 10.1371/journal.pone.015403. PMID: 27105337.
Alhhazmi, A, D. Hurteau, G.J. Tyrrell. 2016. Epidemiology of Invasive Group B Streptococcal Disease in Alberta, Canada, 2003-2013. Journal of Clinical Microbiology. 54(7): 1774-1781. PMID: 27098960.
Suresh, S., G.J. Tyrrell, A. Alhhazmi, S. Escoredo and M. Hawkes. 2016. Recurrent sepsis and neuroinvasive disease in a neonate culture positive for a capsular serotype III group B streptococcus hvgA+ strain: a case report. Journal of Medical Microbiology Case Reports. 3(3): e005034. PMID: 28348758.
Miller, R.R., M.G. Langille, V. Montoya, A. Crisan, A. Stefanovic, I. Martin, L. Hoang, D.M. Patrick, M. Romney, G.J. Tyrrell, S.J. Jones, F.S. Brinkman and P. Tang. 2016. Genomic analysis of a serotype 5 Streptococcus pneumoniae outbreak in British Columbia, Canada 2005-2009. Canadian Journal of Infectious Disease and Medical Microbiology. 2016; 2016:5381871. doi: 10.1155/2016/5381871. Epub 2016 Apr 14. PMID: 27366170.
Demczuk, W., I. Martin, G. Van Domselaar, M. Graham, S. Peterson, A. Bharat, B. Lefebvre, V. Allen, L. Hoang, G.J. Tyrrell, G. Horsman, J. Wylie, D. Haldane, C. Archibald, T. Wong and M.R. Mulvey. 2016. Genomic epidemiology and molecular resistance mechanisms of azithromycin resistant Neisseria gonorrhoeae in Canada from 1997 to 2014. 2016 Mar 2. Pii: Journal of Clinical Microbiology.03195-15 [EPUB ahead of print]. PMID: 27366170.
Tsang, R.S.W., A. Li, A. Muller, M. Baikie, K. Whyte, M. Shuel, G.J. Tyrrell, J.A.L. Rotondo, S. Desai and J. Spika. 2016. Laboratory characterization of invasive Haemophilus influenzae isolated from Nunavut, Canada, 2000-2012. International Journal of Circumpolar Health. 75:29798, http://dx.doi.org/10.3402/ijch.v75.29798. PMID: 28156415.
2015
Hamula, C., H. Peng, Z. Wang, G.J. Tyrrell, X-F. Li and X.C. Le. 2015. An improved SELEX technique for selection of DNA aptamers binding to M-type 11 of Streptococcus pyogenes. Methods. 97:51-57. PMID: 26678795.
Shigayeva, A., W. Rudnick, K. Green, G.J. Tyrrell, W. Demczuk, W. Gold, J. Gubbay, F. Jamieson, A. Plevneshi, S. Pong-Porter, S. Richardson, A. McGeer and the Toronto Invasive Diseases Network. 2015. Association of serotype with respiratory presentations of pneumococcal infection, Ontario, Canada, 2003-2011. Vaccine. 34(6): 846-853. PMID: 26602266.
Hamula, C.L.A., H. Peng, Z. Wang, A.M. Newbigging, G.J. Tyrrell, X.F. Li and X.C. Le. 2015. The effects of SELEX conditions on the resultant aptamer pools in the selection of aptamers binding to bacterial cells. Journal of Molecular Evolution. 81(5-6):194-206. PMID: 26538121.
Good, M.F., M. Pandey, M.R. Batzloff and G.J. Tyrrell. 2015. Strategic development of the conserved region of the M protein and other candidates as vaccines to prevent infection with Group A streptococci. Expert Review of Vaccines. 14(11):1459-1470. PMID: 26485214.
Shigayeva, A, W. Rudnick, K. Green, D. Chen, W. Demzcuk, W. Gold, J. Johnstone, I. Kitai, S. Krajden, R. Lovinsky, M. Muller, J. Powis, N. Rau, S. Walmsley, G.J. Tyrrell, A. McGeer. 2015. Invasive pneumococcal disease among immunocompromised persons: implications for vaccination programs. Clinical Infectious Diseases. 2015 Sep 9. PMID: 26354970.
Sawatzky, P., G. Liu, J.R. Dillon, V. Allen, B. Lefebvre, L. Hoang, G.J. Tyrrell, P. van Caeseele, P. Levett, and I. Martin. 2015. Quality assurance for antimicrobial susceptibility testing of Neisseria gonorrhoeae in Canada 2003 to 2012. Journal of Clinical Microbiology. 53(11):3646-3649. PMID: 26338862.
Peterson, S.W., I. Martin, W. Demczuk, A. Bharat, L. Hoang, J. Wylie, V. Allen, B. Lefebvre, G.J. Tyrrell, G. Horsman, D. Haldane, R. Garceau, T. Wong and M.R. Mulvey. 2015. Molecular assay for the detection of ciprofloxacin resistance in Neisseria gonorrhoeae from cultures and clinical nucleic acid amplification test (NAAT) specimens. Journal of Clinical Microbiology. 53(11):3606-3608. PMID: 26292300.
Peterson, S.W., I. Martin, W. Demczuk, A. Bharat, L. Hoang, J. Wylie, V. Allen, B. Lefebvre, G.J. Tyrrell, G. Horsman, D. Haldane, R. Garceau, T. Wong and M. Mulvey. 2015. Molecular assay for the detection of genetic markers associated with decreased susceptibility to cephalosporins in Neisseria gonorrhoeae. Journal of Clinical Microbiology. 53(7):2042-2048. PMID: 25878350.
Gounder, P.P., T. Zulz, S. Desai, F. Stenz, K. Rudolph, R. Tsang, G.J. Tyrrell and M.G. Bruce. 2015. Epidemiology of meningitis caused by Haemophilus influenzae, Neisseria meningitdis and Streptococcus pneumoniae in North American Arctic, 2000-2010. Journal of Infection. 71(2):178-187. PMID: 25864638.
Waye, A., A. Chuck, P. Jacobs, G.J. Tyrrell, J.D. Kellner, V. Remple. 2015. Prevnar 7 childhood immunization program in pneumococcal incidence and resulting impact on health care costs in Alberta (2003-2008). Drugs – Real World Outcomes. 2(2):153-161.
Tsang, R.S., L. Hoang, G.J. Tyrrell, G. Horsman, J. Wylie, F. Jamieson, B. Lefebvre and M. Taha. 2015. Genetic and antigenic characterization of Canadian invasive Neisseria meningitidis serogroup C (MenC) case isolates in the post MenC-conjugate vaccine era, 2009-2013. Journal of Medical Microbiology. 64(Pt2):174-179. PMID: 25587078.
Simmonds, D.K., S. Fathima, L. Chui, M. Lovgren, P. Shook, M. Shuel, G.J. Tyrrell, R. Tsang, S.J. Drews. 2015. Dominance of two genotypes of Bordetella pertussis during a period of increased pertussis activity in Alberta, Canada: January 2012 - August 2012. International Journal for Infectious Diseases. 29:223-225. PMID: 25462185.
Demczuk, W., T. Lynch, I. Martin, G. Van Domselaar, M. Graham, A. Bharat, V. Allen, L. Hoang, B. Lefebvre, G.J. Tyrrell, G. Horsman, D. Haldane, R. Garceau, J. Wylie, T. Wong, and M. Mulvey. 2015. Whole-genome phylogenetic heterogeneity of Neisseria gonorrhoeae with decreased cephalosporin susceptibility collected in Canada between 1989 and 2013. Journal of Clinical Microbiology. 53(1):191-200. PMID: 25378573.
2014
Law, D., J. Zhou, S. Deng, L. Hoang, G.J. Tyrrell, G. Horsman, J. Wylie and R.S. Tsang. 2014. Determination of serotyping antigens, clonal analysis and genetic characterization of the 4CMenB vaccine antigen genes in invasive Neisseria meningitidis from western Canada, 2009 to 2013. Journal of Medical Microbiology. 63(Pt11):1490-1499. PMID: 25165123.
Green, K., A, McGeer, W. Rudnick, S. Pong-Porter, S. Patel, D.E. Low and the Canadian Bacterial Diseases Surveillance Network (G.J. Tyrrell – member). 2014. in vitro activity of new cephalosporins vs Streptococcus pneumoniae from the Canadian bacterial surveillance network: 2008-2011. Current Microbiology. 69(5):763-767. PMID: 25023636.
2013
Demczuk, W., I. Martin, A. Griffith, B. Lefebvre, A. McGeer, M. Lovgren, G.J. Tyrrell, S. Desai, L. Sheeard, H. Adam, M. Gilmour, G. Zhanel. 2013. Serotype distribution of invasive Streptococcus pneumoniae in Canada after the introduction of the 13-valent pneumococcal conjugate vaccine, 2010-2012. Canadian Journal of Microbiology. 59(12):778-788. PMID: 24313450.
Rudick, W., Z. Liu, A. Shigayeva, D. Low, K. Green, A. Plevneshi, R. Devlin, J. Downey, K. Katz, I. Kitai, S. Krajden, K. Ostrowska, D. Richardson, S. Richardson, A. Sarabia, M. Siverman, A. Simor, G.J. Tyrrell, A. McGeer, Toronto Invasive Diseases Network. 2013. Pneumococcal vaccination programs and the burden of invasive pneumococcal disease in Ontario, Canada, 1995-2011. Vaccine. 31(49):5863-5871. PMID: 24099873.
Feikin, D.R., E.W. Kagucia, J. Loo, R. Link-Gelles, M. Puham, T. Cerian, O.S. Levine, C.G. Whitney, K. O’Brien, M.R. Moore and the Serotype Replacement Group (G.J. Tyrrell-member). 2013. Serotype-specific changes in invasive pneumococcal disease after pneumococcal conjugate vaccine introduction – a pooled analysis of multiple surveillance sites. PLoS Med. 10(9):e1001517. PMID: 24086113.
Fittipaldi, N., G.J. Tyrrell, D.E. Low, I. Martin, D. Lin, K.L. Hari and J.M. Musser. 2013. Integrated Whole-Genome Sequencing and Temporospatial Analysis of a Continuing Group A Streptococcus Epidemic. Emerging Microbes and Infection. EPUB. 2,e13. Mar 27, 2013. PMID: 26038455.
Ahmed, R.A., C. Shandro, G.J. Tyrrell, M.K. Sharma, and L.J. Miedzinski. 2013. Safety of injecting insulin through clothes: a case of Mycobacterium immunogenum cutaneous infection and review of the literature. Clinical Diabetes. 31(2):76-78.
Hoefsloot, W., J. van Ingen, C. Andrejak, K. Ängeby, R. Bauriaud, P. Bemer, M.J. Boeree, J. Cacho , E. Chimara, R. Cias, R. Dasa, P.N.R. Dekhuijzen, D. Domingo, F. Drobniewski, J. Esteban, M. Fauville-Dufaux, D.B. Folkvardsen, N. Gibbons, E. Gómez-Mampaso , R. Gonzalez , H. Hoffmann, P.R. Hsueh, A. Indra, T. Jagielski, F. Jamieson, M. Jankovic, J. Keane, W.J. Koh, S. Leao, R. Macedo, T. Mannsåker, T. Marras, J. Maugein, H. Milburn, T. Mlinkó, N. Morcillo, K. Morimoto, D. Papaventis, E. Palenque, M. Paez-Peña, C. Piersimoni, M. Polanová, N. Rastogi, E. Richter, M.J. Ruiz-Serrano, A. Silva, H. Simsek, D. van Soolingen, N. Szabó, R. Thomson, M.T. Tórtola Fernandez, E. Tortoli, S.E. Totten, G.J. Tyrrell, T. Vasankari, M. Villar, R. Walkiewicz, K. Winthrop, D. Wagner for NTM-NET. 2013. The geographic diversity of nontuberculous mycobacteria isolated from pulmonary samples: An NTM-net collaborative study. European Respiratory Journal. 42(6): 1604-1613. PMID: 23598956.
Doucette, K., M. Al-Saif, N. Kneteman, L. Chui, G.J. Tyrrell, D. Kumar and A. Humar. 2013. Donor-derived bacteremia in liver transplant recipients despite antibiotic prophylaxis. American Journal of Transplantation. 13(4):1080-1083. PMID: 23398841.
2012
LeBlanc, J, D. Webster, G.J. Tyrrell and I. Chiu. 2012. Mycobacterium marinum infection from Sea Monkeys. Canadian Journal of Infectious Diseases and Medical Microbiology. 23(4):e106-e108. PMID: 24294280.
Crago, C., C. Ferrato, S.J. Drews, L. Svenson, G.J. Tyrrell and M. Louie. 2012. Prevalence of Staphylococcus aureus in food samples associated with foodborne samples associated with foodborne illness in Alberta, Canada from 2007-2010. Food Microbiology. 32(1):202-205. PMID: 22850394.
Demczuk, W., I. Martin, A. Griffith, B. Lefebvre, A. McGeer, A. Shane, G. Zhanel, G.J. Tyrrell, M. Gilmour, Toronto Invasive Diseases Network, and Canadian Public Health Laboratory network. 2012. Serotype Distribution of invasive Streptococcus pneumoniae in Canada during the introduction of the 13-valent pneumococcal conjugate vaccine, 2010. Canadian Journal of Microbiology. 58(8):1008-1017. PMID: 22827750.
Boone, T.J. and G.J. Tyrrell. 2012. Identification of the Actin and Plasminogen Binding Regions of Group B Streptococcal phosphoglycerate kinase. Journal of Biological Chemistry. 287(34):29035-29044. PMID: 22761440.
Leal, J., O.G. Vanderkooi, D. Church, J. MacDonald, G.J. Tyrrell and J. Kellner. 2012. Eradication of invasive pneumococcal disease (IPD) due to the 7-valent Pneumococcal Conjugate Vaccine (PCV7) serotypes in Calgary, Alberta. Pediatric Infectious Diseases Journal. 31(9):e169-e175. PMID: 22673137.
Tyrrell, G.J., M. Lovgren, S. Garg, L. Chui, T.J. Boone, C. Mangan, D. Patrick, L. Hoang, G. Horsman, P. van Caeseele and T.J. Marrie. 2012. A Streptococcus pneumoniae serotype 5 disease epidemic in western Canada: 2005-2009. Emerging Infectious Diseases. 18(5); 733-740. PMID: 22515944.
Boone, T.J. and G.J. Tyrrell. 2012. Identification of Genes Affecting Expression of Phosphoglycerate Kinase on the Surface of Group B Streptococcus. Canadian Journal of Microbiology. 58:433-441. PMID: 22444251.
Fittipaldi, N.V., S.B. Beres, R.J. Olsen, V. Kapur, P.R. Shea, M.E. Watkins, C. Cantu, D. R. Laucirica, L. Jenkins, A.R Flores, M. Lovgren, G. Spire, C. Ardanuy, J. Linares, D.E. Low, G.J. Tyrrell and J.M. Musser.2012. Full genome dissection of an epidemic of severe invasive disease caused by a hyper virulent, recently emerged clone of group A streptococcus. American Journal of Pathology. 180(4):1522-1534. PMID: 22330677.
Olsen, R.J., D. Laucerica, M.E. Watkins, M. Feske, J. R. Garcia-Bustillos, C. Vu, C. Cantu, S.A. Shelburne III, N. Fittipaldi, M. Kumaraswami, P.R. Shea, A.R. Flores, S. B. Beres, M. Lovgren, G.J. Tyrrell, A. Efstratiou, D.E. Low, C.A. Van Beneden, and J.M. Musser. 2012. Polymorphisms in regulator of protease B (RopB) alter disease phenotype and strain virulence of serotype M3 Group A Streptococcus. Journal of Infectious Diseases. 205(11):1719-1729. PMID: 22262791.
Sahni, V., M. Naus, L. Hoang, G.J. Tyrrell, I. Martin, and D.M. Patrick. 2012. The epidemiology of invasive pneumococcal disease in British Columbia following implementation of an infant immunization program: increases in herd immunity and replacement disease. Canadian Journal of Public Health. 103(1):29-33. PMID: 22338325.
2011
Sharma, M., L. Thibert, P. Chedore, C. Shandro, F. Jamieson, G.J. Tyrrell, S. Christianson, H. Soualhine and J. Wolfe. 2011. A Canadian multicentre laboratory study for standardized second-line antimicrobial susceptibility testing of Mycobacterium tuberculosis. Journal of Clinical Microbiology. 49(12):4112-4116. PMID: 21998413.
Johnstone, J., G.J. Tyrrell, T.J. Marrie, S. Garg, J. Kellner and the SPAT Group. 2011. Streptococcus pneumoniae meningitis in a large Canadian population pre and post introduction of the 7-valent pneumococcal conjugate vaccine. Canadian Journal of Infectious Disease and Medical Microbiology. 22(4):137-141. PMID: 23205025.
Talavlikar, R., B. Meatherill, S. Desai, J. Carson, S. Kuhn, M. Sharma, C. Shandro and G.J. Tyrrell. 2011. Mycobacterium senegalense tissue infection in a child related to fish tank exposure. Canadian Journal of Infectious Disease and Medical Microbiology. 22(3):101-103. PMID: 22942887.
Boone, T.J., C.D. Burnham and G.J. Tyrrell. 2011. Binding of Group B Streptococcal Phosphoglycerate Kinase to Plasminogen and Actin. Microbial Pathogenesis. 51(4):255-261. PMID: 21729749.
Kuster, S.P., A.R. Tuite, J.C. Kwong, A. McGeer, the Toronto Invasive Bacterial Diseases Network (G.J. Tyrrell-member) and D.N. Fisman. 2011. Evaluation of co-seasonality of influenza and invasive pneumococcal disease; results from prospective surveillance. PLoS Medicine. 8(6); e1001042. PMID: 21687693.
Patel, S.N., A. McGeer, R. Melano, G.J. Tyrrell, K. Green, D.R. Pillai and D.E. Low. 2011. Susceptibility of Streptococcus pneumoniae to fluoroquinolones in Canada. Antimicrobial Agents and Chemotherapy 55(8):3703-3708. PMID: 21628545.
Jacobs, S., A. Warman, R. Richardson, W. Yacoub, A. Lau, D. Whittaker, S. Cockburn, G. Verma, J. Boffa, G.J. Tyrrell, D. Kunimoto, J. Manfreda and R. Long. 2011. The tuberculin skin test is unreliable in low risk bacilli calmette-guerin (BCG) – vaccinated school children. Pediatric Infectious Diseases Journal 30(9):754-758. PMID: 21487326.
Marrie, T.J., G.J. Tyrrell, S. Garg, O.G. Vanderkooi. 2011. Factors predicting mortality in invasive pneumococcal disease. Medicine (Baltimore) 90(3):171-179. PMID: 21512414.
Tyrrell, G.J. 2011. The changing epidemiology of Streptococcus pneumoniae serotype 19A. Invited Editorial. Journal of Infectious Diseases. 203(10):1345-1347. PMID: 21398394.
2010
Tyrrell, G.J., M. Lovgren, T. St. Jean, L. Hoang, D. Patrick, G. Horsman, P. van Caeseele, L. E. Sieswerda, A. McGeer, R. A. Laurence, AM. Bourgault and D.E. Low. 2010. Epidemic of group A streptococcus M/emm59 causing invasive disease in Canada. Clinical Infectious Diseases. 51(11):1290-1297. PMID: 21034198.
Olsen, S-R, R. Long, G.J. Tyrrell and D. Kunimoto. 2010. Induced sputum for the diagnosis of pulmonary tuberculosis: is it useful in clinical practice? Canadian Respiratory Journal, 17(4):e81-e84. PMID: 20808978.
Wong, A., T.J. Marrie, S. Garg, J.D. Kellner and G.J. Tyrrell. 2010. Welders are at Increased Risk for Pneumococcal Disease. International Journal of Infectious Disease. 14(9):e796-799. PMID: 20637673.
Chuck, A., P. Jacobs, G.J. Tyrrell and J.D. Kellner. 2010. Pharmaco-economic evaluation of 10 and 13-valent pneumococcal conjugate vaccines. Vaccine. 28(33):5485-5490. PMID: 20554066.
Wong, A., T.J. Marrie, S. Garg, J.D. Kellner, G.J. Tyrrell. 2010. Increased risk of invasive pneumococcal disease in hematologic and solid-organ malignancies. Epidemiology and Infection. 138(12):1804-1810. PMID: 20429967.
Waisman, D.C., G.J. Tyrrell, J.D. Kellner, S. Garg and T.J. Marrie. 2010. Pneumococcal peritonitis – still with us and likely to increase in importance. Canadian Journal of Infectious Diseases and Medical Microbiology 21(1):e23-27. PMID: 21358876.
Beres, S.B., R.K. Carroll, P.S. Shea, I. Sitkiewicz, J. C. Martinez-Gutierrez, D.E. Low, A. McGeer, B. Willey, K. Green, G.J. Tyrrell, T.D. Goldman, M. Feldgarden, B.W. Birren, Y. Fofanov, J. Boos, W.D. Wheaton, C. Honisch and J.M. Musser. 2010. Molecular complexity of successive bacterial epidemics deconvoluted by deep-genome sequencing and systems biology analysis. Proceedings of the National Academy of Sciences (PNAS), 107(9):4371-4376. PMID: 20142485.
Bettinger, J.A., D.W. Scheifele, J.D. Kellner, S.A. Halperin, W. Vaudry, B. Law and G.J. Tyrrell. 2010. The effect of routine vaccination on invasive pneumococcal infections in Canadian children, immunization monitoring program, active 2000-2007. Vaccine. 28(9): 2130-2136. PMID: 20044050.
Liu, Y., C. Wang, G.J. Tyrrell and XF Li. 2010. Production of Shiga-like toxins in viable but nonculturable Escherichia coli O157:H7. Water Research. 44(3):711-718. PMID: 19879621.
2009
Plevneshi, A., T. Svoboda, I. Armstrong, G.J. Tyrrell, A. Miranda, K. Green, A. McGeer, the Toronto Invasive Bacterial Diseases Network. 2009. Invasive Pneumococcal disease in homeless adults in Toronto: five years of population-based surveillance. PLoS One. Sept 29, 4(9):e7255. PMID: 19787070.
Kellner, J.D., O.G. Vanderkooi, J. MacDonald, D.L. Church, G.J. Tyrrell and D. Scheifele. 2009. Changing epidemiology of invasive pneumococcal disease in Canada 1998 to 2007: update from the Calgary Area Streptococcus pneumoniae research (CASPER) study. Clinical Infectious Diseases. 49(2):205-212. PMID: 19508165.
Tyrrell, G.J., M. Lovgren, N. Chui, J. Minion, S. Garg, J.D. Kellner and T.J. Marrie. 2009. Serotypes and antimicrobial susceptibilities of invasive Streptococcus pneumoniae pre and post 7-valent pneumococcal conjugate vaccine introduction in Alberta, Canada, 2000 to 2006. Vaccine. 27(27):3553-3560. PMID: 19464534.
Kunimoto, D., E. Der, A. Beckon, L. Thomas, M. Egedahl, A. Beatch, G. Williams, G.J. Tyrrell, R. Ahmed, N. Brown and R. Long. 2009. Use of the QuantiFERON®-TB GOLD Test to Confirm Latent Tuberculosis Infection in a Canadian Tuberculosis Clinic. International Journal of Tuberculosis and Lung Disease. 13(6):726-730. PMID: 19460248.
Chan, W.W., M. Lovgren and G.J. Tyrrell. 2009. Utility of the PneumoslideTM Test in Identification of Streptococcus pneumoniae in Blood Cultures and its Relation to Capsular Serotype. Journal of Clinical Microbiology, 47(5):1559-1561. PMID: 19321721.
Liu, Y., C. Wang, G.J. Tyrrell, S.E. Hrudey and X-F. Li. 2009. Induction of Escherichia coli O157:H7 into the viable but non-culturable state by chloraminated water and river water, and subsequent resuscitation. Environmental Microbiology Reports. 1(2):155-161. PMID: 23765746.
Pang, X., B.E. Lee, G.J. Tyrrell and J.K. Preiksaitis. 2009. Epidemiology and genotype analysis of Sapovirus in gastroenteritis outbreaks in Alberta, 2004-2007. Journal of Infectious Diseases. 199(4):547-551. PMID: 19099483.
2008
Lam, M., R. Verity, G.J. Tyrrell, R. Arndt, J. Nigrin and S.E. Forgie. 2008. Gram-negative bacteremia and asplenia in a well 15 year old. Canadian Journal of Infectious Diseases and Medical Microbiology. 19(6):391-392. PMID: 19436566.
Kellner, J.D., D. Scheifele, O. G. Vanderkooi, J. Macdonald, D. L. Church and G.J. Tyrrell. 2008. Effects of Routine Infant Vaccination with the 7-Valent Pneumococcal Conjugate Vaccine on Nasopharyngeal Colonization with Streptococcus pneumoniae in Children in Calgary, Canada. Pediatric Infectious Disease Journal, 27(6):526-532. PMID: 18458650.
Chui, L., T. Chiu, J. Kakulphimp and G.J. Tyrrell. 2008. A comparison of three real time PCR assays for the confirmation of Neisseria gonorrhoeae following Roche COBAS AMPLICOR Neisseria gonorrhoeae detection. Clinical Microbiology and Infection, 14(5):473-479. PMID: 18294244.
Dawar, M., B. Russell, K. McClean, P. Levett, G.J. Tyrrell and J. Irvine. 2008. A case of necrotizing fasciitis due to Streptococcus pneumoniaeserotype 5 in Saskatchewan. Canadian Journal of Infectious Diseases and Medical Microbiology, 19(1):69-71. PMID: 19145265.
Kumar, D., A. Humar, A. Plevneshi, D. Siegal, N. Franke, K. Green, A. McGeer, and the Toronto Invasive Bacterial Disease Network (G.J. Tyrrell – member). 2008. Invasive pneumococcal disease in adult hematopoietic stem cell transplant recipients: a decade of prospective population-based surveillance. Bone Marrow Transplantation. 41:743-747. PMID: 18176614.
Bruce, M.G., S.L. Deeks, T. Zulz, D. Bruden, C. Navarro, M. Lovgren, C. Palacios, C. Case, C. Hemsley, T. Hennessy, A. Corriveau, B. Larke, I. Sobel, M. Lovgren, C. Debyle, R. Tsang, A. Parkinson and the International Circumpolar Surveillance Hia Working Group (G.J. Tyrrell – member). 2008. Epidemiology of Haemophilus influenzae serotype a, North American Arctic, 2000-2005. Emerging Infectious Diseases. 14:48-55. PMID: 18258076.
Bruce, M.G., S.L. Deeks, T. Zulz, D. Bruden, C. Navarro, M. Lovgren, L. Jette, K. Kristinsson, G. Sigmundsdottir, K. B. Jensen, O. Lovoll, J.P. Nuorti, E. Herva, A. Nystedt, A. Sjosted, A. Koch, T.W. Hennessy, A. Parkinson and the International Circumpolar Surveillance System for Invasive Pneumococcal Disease Working Group (G.J. Tyrrell – member). 2008. International Circumpolar Surveillance System for Invasive Pneumococcal Disease, 1999-2005. Emerging Infectious Diseases. 14:25-33. PMID: 18258073.
Degani, N., C. Navarro, S.L. Deeks, M. Lovgren and the Canadian International Circumpolar Surveillance Working Group (G.J. Tyrrell – member). 2008. Invasive Bacterial Diseases in Northern Canada. Emerging Infectious Diseases. 14:34-40. PMID: 18258074.
Burgess, T., A.F. Hirschfeld, G.J. Tyrrell, J.A. Bettinger and S.E. Turvey. 2008. Commonly invasive serotypes of Streptococcus pneumoniaetrigger a reduced innate immune response compared with serotypes rarely responsible for invasive infection. FEMS Immunology and Medical Microbiology. 53(1):136-139. PMID: 18248437.
Winters, M., D. Patrick, F. Marra, J. Buxton, M. Chong, J. Isaac-Renton, C. Shaw, G.J. Tyrrell, M. Lovgren, and S. Paulus. 2008. Epidemiology of invasive pneumococcal disease in B.C. during the introduction of conjugated pneumococcal vaccine. Canadian Journal of Public Health. 99(1):57-61. PMID: 18435393.
Shahidi, N., J. Dhaliwal, G.J. Tyrrell, L. Hoang and D. Patrick. 2008. Trends in incidence of invasive pneumococcal disease following introduction of the universal infant immunization program in British Columbia, 2002-2006. BC Medical Journal. 50:18-21
2007
Lovgren, M., J. A. Talbot, E. Castañeda, M. C. Brandileone, G. Echániz-Avilés, M. Hortal, M. Regueira, I. Heitmann, J. L. di Fabio and the SIREVA Study Group (G.J. Tyrrell-member). 2007. The SIREVA Project 1993-2005: The Evolution of an International EQA Model. Journal of Clinical Microbiology. 45:3184-3190. PMID: 17687007.
Neal, S., B. Beall, K. Ekelund, B. Henriques-Normark, A. Jasir, D. Johnson, E. Kaplan, M. Lovgren, R. Reinert, members of the International Streptococcus Reference Laboratories (G.J. Tyrrell – member) and A. Efstratiou. 2007. International Quality Assurance for the Characterisation of Streptococcus pyogenes. Journal of Clinical Microbiology. 45:1175-1179. PMID: 17267628.
Burnham, C.D., S. Shokoples, and G.J. Tyrrell. 2007. Invasion of HeLa cells by group B streptococcus requires the phosphoinositide-3-kinase signaling pathway and modulates phosphorylation of host-cell Akt and glycogen synthase kinase-3. Microbiology-SGM. 153(Pt12):4240-4252. PMID: 18048937.
Flavelle, S., G.J. Tyrrell and S.E. Forgie. 2007. A serious bloodstream infection in an infant. Canadian Journal of Infectious Diseases and Medical Microbiology. 18(5):311-312.
Daneman, N., K.A. Green, D.E. Low, A.E. Simor, B. Willey, B. Schwartz, B. Toye, P. Jessamine, G.J. Tyrrell, S. Krajden, L. Ramage, D. Rose, R. Schertzberg, D. Bragg, A. McGeer, and the Ontario Group A Streptococcal Study Group. 2007. Surveillance for hospital outbreaks of invasive group A streptococcal infections in Ontario, Canada, 1992-2000. Annals of Internal Medicine. 147(4):234-241. PMID: 17709757.
Webster, D., L. Chui, G.J. Tyrrell and T.J. Marrie. 2007. Healthcare-associated Staphylococcus aureus pneumonia. Canadian Journal of Infectious Diseases and Medical Microbiology. 18(3):181-188. PMID: 18923721.
Bjornson, G., D. W. Scheifle, J. Bettinger, D. Patrick, L. Gustafson, P. Daly and G.J. Tyrrell. 2007. Effectiveness of pneumococcal conjugate vaccine in greater Vancouver, Canada: 2004-2005. Pediatric Infectious Diseases Journal. 26(6):540-542. PMID: 17529875.
Burnham, C.D., S. Shokoples and G.J. Tyrrell. 2007. Rac1, RhoA and Cdc42 participate in HeLa cell invasion by group B streptococcus. FEMS Microbiology Letters. 272(1):8-14. PMID: 17517067.
Marra, F., D.L. Monnet, D.M. Patrick, M. Chong, C. Brandt, M. Winters, M. Kaltoft, G.J. Tyrrell, M. Lovgren, W.R. Bowie. 2007. A comparison of antibiotic use in children between Canada and Denmark. Annals of Pharmacotherapy. 41(4):659-666. PMID: 17374628.
Bettinger, J.A., D.W. Scheifle, S. Halperin, J.D. Kellner, G.J. Tyrrell and Members of the Canadian Paediatrics Society’s Immunization Monitoring Program, Active (IMPACT). 2007. Invasive pneumococcal infections in Canadian children, 1998-2003: Implications for vaccine programs. Canadian Journal of Public Health. 98(2):111-115. PMID: 17441533.
2006
Wetsch, N., K. Somani, G.J. Tyrrell, C. Gelbhart, R.J. Bailey and D.E. Taylor. 2006. Campylobacter curvus associated hepatic abscesses: A case report. Journal of Clinical Microbiology. 44(5):1909-1911. PMID: 16672438.
Jayaraman, J., A.E. Singh, N. Yiannakoulias, J. Gratrix, B. Anderson, M. Johnson, L. Svenson, B. Kress, G.J. Tyrrell, and T. Wong. 2006. Sub-regional variations in the epidemiology of Neisseria gonorrhea in a large urban region in Alberta, Canada: results from spatial analyses using routinely collected surveillance data. Canada Communicable Disease Report 32(4):29-38.
Anderson, H., L. Honish, G. Taylor, M. Johnson, C. Tovstiuk, E.A, Fanning, G.J. Tyrrell, R. Rennie, J. Jaipaul, C. Sand and S. Probert. 2006. Histoplasmosis cluster, Golf Course, Canada. Emerging Infectious Diseases. 12(1):163-165. PMID: 16494738.
Public Health Agency of Canada Invasive Group A Streptococcus Working Group (G.J. Tyrrell - member). 2006. Guidelines for the Prevention and Control of Invasive Group A Streptococcal Disease. Canada Communicable Disease Report 32S2:1-26.
2005
Kellner, J.D., D.L. Church, J. MacDonald, G.J. Tyrrell and D. Scheifle. 2005. Progress in the Prevention of Pneumococcal Infection: The Calgary area Streptococcus pneumoniae epidemiology research (CASPER) study. Canadian Medical Association Journal (CMAJ). 173(10):1149-1151. PMID: 16275962.
Sikora, C., J. Speilman, K. Macdonald, G.J. Tyrrell and J.M. Embil. 2005. Necrotizing fasciitis resulting from human bites: A report of two cases of disease caused by Group A streptococci. Canadian Journal of Infectious Diseases and Medical Microbiology. 16(4):221-224. PMID: 18159548.
Anderson, H., G. Taylor, E.A. Fanning, L. Honish, M. Johnson, J. Jaipaul, S. Probert, C. Tovstiuk, G.J. Tyrrell, R. Rennie, and C. Sand. 2005. Locally-acquired histoplasmosis cluster, Alberta, 2003. Canada Communicable Disease Report. 31(24):1-3.
Vanderkooi, O.G., D.E. Low, K. Green, J.E. Powis, A. McGeer and the Toronto Invasive Bacterial Disease Network (G.J. Tyrrell–member). 2005. Predicting Antimicrobial Resistance in Invasive Pneumococcal Infections. Clinical Infectious Disease, 40:1288-1297. PMID: 15825031.
Daneman, N., A. McGeer, D. E. Low, G.J. Tyrrell, A.E. Simor, M. McArthur, B. Schwartz, P. Jessamine, R. Croxford, K.A. Green, Ontario Group A Streptococcal Study Group. 2005. Hospital-acquired invasive group A streptococcal infections in Ontario, Canada, 1992-2000. Clinical Infectious Diseases. 41(3):334-342. PMID: 16007530.
Honish, L., N. Hislop, I. Zazulak, L. Chui and G.J. Tyrrell. 2005. Restaurant Food-handler-Associated Outbreak of Salmonella Heidelberg Gastroenteritis Identified by Calls to a Local Telehealth Service – Edmonton, Alberta, 2004. Canada Communicable Disease Report, 31(10):1-5.
Burnham, C.D., S. E. Shokoples and G.J. Tyrrell. 2005. Phosphoglycerate Kinase Inhibits Epithelial Cell Invasion by Group B Streptococci. Microbial Pathogenesis. 38(5-6):189-200. PMID: 15925270.
Shariatzadeh, M.R., J.Q. Huang, G.J. Tyrrell, M.M. Johnson and T.J. Marrie. 2005. Bacteremic pneumococcal pneumonia: A prospective study in Edmonton and neighbouring municipalities. Medicine. 84(3):147-161. PMID: 15879905.
Tyrrell, G.J., M. Lovgren, B. Kress and K. Grimsrud. 2005. Invasive Group A streptococcal disease in Alberta, Canada, 2000-2002. Journal of Clinical Microbiology. 43(4):1678-1683. PMID: 15814984.
Tyrrell, G.J., M. Lovgren, B. Kress and K. Grimsrud. 2005. Varicella Associated Invasive Group A streptococcal disease in Alberta, Canada, 2000-2002. Clinical Infectious Diseases. 40(7):1055-1057. PMID: 15825001.
2003
Ng, L., I. Martin, A. Lau and the National Gonococcal Surveillance Program Members (G.J. Tyrrell–member). 2003. Trends of Chromosomal-Mediated Resistance in Neisseria gonorrhoeae in Canada. Journal of Sexually Transmitted Diseases, 30:896-900. PMID: 14646637.
Burnham, C.D. and G.J. Tyrrell. 2003. Virulence Factors of Group B Streptococcus. Review. Reviews in Medical Microbiology, 14(4):109-118.
Vanderkooi, O.G., J.D. Kellner, A.W. Wade, T. Jadavji, J.P. Midgley, T. Louie and G.J. Tyrrell. 2003. Invasive Streptococcus pneumoniae infection causing haemolytic uremic syndrome in children: two recent cases. Canadian Journal of Infectious Diseases and Medical Microbiology. 14:339-343.
Smith, A., A. Li, O. Tolomeo, G.J. Tyrrell, F. Jamieson and D. Fisman. 2003. Mass antibiotic treatment for Group A streptococcus in two-long term care facilities. Emerging Infectious Diseases. 9(10):1260-1265. PMID: 14609461.
Facklam, R.R., M. Lovgren, P. L. Shewmaker and G.J. Tyrrell. 2003. Phenotypic Description and antimicrobial susceptibilities of Aerococcus sanguicola from human clinical samples. Journal of Clinical Microbiology. 41(6):2587-2592. PMID: 12791884.
Desai, T.R, G.J. Tyrrell, T. Ng and W.H. Finlay. 2003. In vitro evaluation of nebulization properties, antimicrobial activity and regional airway surface liquid concentration of liposomal Polymyxin B sulfate. Pharmaceutical Research. 20(3):442-447. PMID: 12669966.
2002
Tyrrell, G.J., A. Kennedy, S.E. Shokoples and R. Sherburne. 2002. Binding and Invasion of HeLa and MRC-5 Cells by Streptococcus agalactiae. Microbiology-SGM. 148(Pt12):3921-3931. PMID: 12480896.
Tyrrell, G.J., M. Lovgren, B. Forwick, N. P. Hoe, J.M. Musser and J.A. Talbot. 2002. M Types of Group A streptococci isolates submitted to the National Centre for Streptococcus (Canada): 1993-1999. Journal of Clinical Microbiology. 40(12):4466-4471. PMID: 12454137.
Tyrrell, G.J., L. Chui, M. Johnson, N. Chang, R. Rennie, J. Talbot and the Edmonton Meningococcal Study Group. 2002. Outbreak of Neisseria meningitidis in Edmonton, Alberta. Emerging Infectious Diseases. 8(5):519-521. PMID: 11996690.
Tyrrell, G.J., L. Turnbull, J. Lefebrve, L. Teixeria, R.R. Facklam and M. Lovgren. 2002. Enterococcus gilvus sp. nov., and Enterococcus pallenssp. nov., isolated from human clinical specimens. Journal of Clinical Microbiology. 40(4):1140-1145. PMID: 11923322.
Facklam, R.R., D. Martin, M. Lovgren, D. Johnson, A. Efstratiou, T. Thompson, S. Gowan, P. Kriz, G.J. Tyrrell, E. Kaplan, B. Beall. 2002. Extension of the Lancefield classification scheme for Group A streptococci by addition of 22 new M protein gene sequence types from clinical isolates: emm103 to emm124. Clinical Infectious Diseases. 34(1):28-38. PMID: 11731942.
2001
Davies, H.D., S. Raj, C. Adair, J. Robinson, A. McGeer and the Alberta GBS Study Group (G.J. Tyrrell-member). 2001. Population-based active surveillance for neonatal group B streptococcal infections in Alberta, Canada: implications for vaccine formulation. Paediatric Infectious Diseases. 20:879-884. PMID: 11734768.
Davies, H.D., C. Adair, A. McGeer, D. Ma, S. Robertson, M. Mucenski, L. Kowalsky, G.J. Tyrrell and C.J. Baker. 2001. Antibodies to Capsular Polysaccharides of Group B Streptococcus in Pregnant Canadian Women: Relationship to Colonization Status and Infection in the Neonate. Journal of Infectious Diseases. 184:285-291. PMID: 11443553.
Kuhn, S.M., J. Preiksaitis, G.J. Tyrrell, T. Jadavji, D. Church and H.D. Davies. 2001. “Evaluation of potential Factors Contributing to Microbiological Treatment Failure in Streptococcus pyogenes Pharyngitis”. Canadian Journal of Infectious Diseases and Medical Microbiology. 12:33-39. PMID:18159315.
2000
Goh, S.H., R.R. Facklam, M. Chang, E.C. Burns, G.J. Tyrrell, J.E. Hill, D. Chan, C. He, T. Rahim, C. Shaw and S.M. Hemmingsen. 2000. Identification of Enterococcus species and phenotypically similar Lactococcus and Vagococcus species by reverse checkerboard hybridization to chaperonin 60 gene sequences. Journal of Clinical Microbiology. 38(11):3953-3959. PMID: 11060051.
Tyrrell, G.J., L. Senzilet, J. Spika, D. Kertesz, J. Talbot, M. Alagartnam, M. Lovgren and the Sentinel Health Surveillance System Site Coordinators. 2000. “Invasive Disease Due to Group B Streptococcal Infection in Adults: Results from a Canadian Population-Based Active Surveillance Study – 1996”. Journal of Infectious Diseases. 182(1):168-173. PMID: 10882594.
Beall, B., G. Gherardi, M. Lovgren, R.R. Facklam, B.A. Forwick and G.J. Tyrrell. 2000. “emm and sof gene sequence variation in relation to serological typing of opacity-factor-positive group A streptococci” Microbiology-SGM. 146(Pt5):1195-1209. PMID: 10832648.
1999
Zanella, R.C., F. Valdetaro, M. Lovgren, G.J. Tyrrell, S. Bokermann, S.C.G. Almeida, V.S.D. Vieira, M. C. Brandileone. 1999. First Confirmed Case of a Vancomycin-Resistant Enterococcus faecium with a vanA Phenotype from Brazil: Isolation from a Meningitis Case in Sao Paulo. Microbial Drug Resistance. 5:159-162. PMID: 10432277.
Johnston, L., L. Chui, N. Chang, S. Macdonald, M. Mackenzie, W. Kennedy, D. Haldane, R. Bethune, G. Taylor and G.J. Tyrrell. 1999. Cross Canada Spread of MRSA via Transplant Organs. Clinical Infectious Diseases. 29(4):819-23. PMID: 10589896.
Facklam, R., B. Beall, A. Efstratiou, V. Fischetti, D. Johnson, E. Kaplan, P. Kriz, M. Lovgren, D. Martin, B. Schwartz, A. Totolian, D. Bessen, S. Hollingshead, F. Rubin, J. Scott and G.J. Tyrrell. 1999. emm Typing and Validation of Provisional M-Types for Group A Streptococci. Emerging Infectious Diseases. 5(2):247-253. PMID: 10221877.
1997
Mackinnon, M., M. Drebot and G.J. Tyrrell. 1997. “Identification and Characterization of IS1476, an Insertion Sequence-like Element that Disrupts VanY Function in a Vancomycin Resistant Enterococcus faecium.” Antimicrobial Agents and Chemotherapy. 41(8):1805-1807. PMID: 9257766.
Tyrrell, G.J., R. Bethune, B. Willey and D.E. Low. 1997. “Species Identification of Enterococci via Intergenic Ribosomal PCR.” Journal of Clinical Microbiology. 35(5):1054-1060. PMID: 9114380.
1993
Boyd, B., G.J. Tyrrell, M. Maloney, C. Gyles, J.L. Brunton and C.A. Lingwood. 1993. “Alteration of the Glycolipid Binding Specificity of the Pig Oedema Disease Toxin from Globotetraosyl to Globotriaosyl Ceramide Alters In vivo Tissue Targeting and Results in a Verotoxin 1-like Disease in Pigs.” Journal of Experimental Medicine. 177(6):1745-1753. PMID: 8496689.
1992
Stein, P., A. Boodhoo, G.J. Tyrrell, J.L. Brunton and R.J. Read. 1992. “Crystal Structure of the Cell-binding B Oligomer of Verotoxin-1 from E. coli.” Nature. 355(6362):748-750. PMID: 1741063.
Tyrrell, G.J., K. Ramotar, B.W. Toye, B. Boyd, C.A. Lingwood and J.L. Brunton. 1992. “Alteration of the Carbohydrate Binding Specificity of Verotoxins From gal(alpha)1-4 to GalNac(beta)1-3gal and vice versa by Site-Directed mutagenesis of the Binding Subunit.” Proceedings of the National Academy of Sciences (PNAS). 89(2):524-528. PMID: 1731324.
1990
Ramotar, K., B. Boyd, G.J. Tyrrell, J. Gariepy, C.A. Lingwood and J.L. Brunton. December 15, 1990. “Characterization of Shiga-like Toxin I B Subunit Purified from Overproducing Clones of the SLT-I B Cistron.” Biochemical Journal. 272(3):805-811. PMID: 2268304.
1989
Tyrrell, G.J., M.S. Peppler, R.A. Bonnah, C. Clark, P. Chong and G.D. Armstrong. 1989. “Lectin-Like Properties of Pertussis Toxin.” Infection and Immunity. 57(6):1854-1857. PMID: 2722243.